Korean Journal of Pharmacognosy (생약학회지)
- Volume 26 Issue 1
- /
- Pages.47-50
- /
- 1995
- /
- 0253-3073(pISSN)
- /
- 2288-9299(eISSN)
Antitumor Agent from the Rhizome of Anemarrhena asphodeloides
지모(知母)의 항암활성성분에 관한 연구
-
Lee, Seung-Ho
(College of Pharmacy Yeung Nam Univ.)
;
-
Ryu, Shi-Yong
(Korea Research Institute of Chemical Technology (KRICT))
;
-
Choi, Sang-Un
(Korea Research Institute of Chemical Technology (KRICT))
;
- No, Zae-Sung (Korea Research Institute of Chemical Technology (KRICT)) ;
- Kim, Sung-Ki (Korea Research Institute of Chemical Technology (KRICT)) ;
-
Lee, Chong-Ock
(Korea Research Institute of Chemical Technology (KRICT))
;
-
Ahn, Jong-Woong
(Korea Research Institute of Chemical Technology (KRICT))
-
이승호
(영남대학교 약학대학)
;
-
유시용
(한국화학연구소)
;
-
최상운
(한국화학연구소)
;
- 노재성 (한국화학연구소) ;
- 김성기 (한국화학연구소) ;
-
이정옥
(한국화학연구소)
;
-
안종웅
(한국화학연구소)
- Published : 1995.03.30
Abstract
EtOAc soluble part of MeOH extract of Anemarrhena asphodeloides rhizome was evaluated for the cytotoxicity against the five kinds of human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15) in vitro. Bioassay-guided fractionation of EtOAc soluble part led to the isolation of active compound which was identified as timosaponin A-III showed potent cytotoxic activity, but its genin, sarsasapogenin, did not show cell growth inhibition.
Keywords
- Anemarrhena asphodeloides;
- Liliaceae;
- steroidal saponin;
- timosaponin A-III;
- cytotoxicity;
- antitumor agent