The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Sopoongtang on the Cardiovascular System in the Experimental Animals

소풍탕(疎風湯)이 실험동물(實驗動物)의 심혈관계(心血管系)에 미치는 영향(影響)

  • 정장균 (원광대학교 한의과대학 내과학교실) ;
  • 문병순 (원광대학교 한의과대학 내과학교실)
  • Published : 1995.06.30
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Abstract

The present experiment was desinged to investigate the effects of Sopungtang water extracts on the Cardiovascular System in the Experimental Animals. Thus, the changes of blood pressure and heart rate were measured after oral administration. Measurments of Mortality rate were observed for measuring the effect of Sopungtang water extract. Sopungtang water extract against pulmonary thromboembolism induced by collagen the mixture(0.1ml/10g, 2mg/kg B.W) plus serotonin(5mg/kg B.W) in mouse. The effects of Sopungtang water extract were examined by observing the change of collagen-induced platelet aggregation, coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats. The results were summarized as followings. 1. Sopungtang dropped the blood pressure in spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug increased the antithrombin activity in rat and the fibrinogen lyses time was reduced and lyses area was increased. 8. Sopungtang reduced fibrinogen lyses time of rat in vitro assay. According to the above mentioned results, Sopungtang increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin acivity, inhibited the platelet aggregation.

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References

  1. 萬病回春 공廷賢
  2. 醫宗損益 黃度淵
  3. 東醫方劑學 尹吉榮
  4. 東垣十種醫書 李고
  5. 本草思辨가 周伯度
  6. 編註醫學入門 李천
  7. 日藥理誌 v.82 Eclatoninの抗高血壓作用に對す硏究 高柳法康(外)
  8. 東醫臨床要覽 金定濟
  9. 診療要鑑 金定濟
  10. 肝系內科學 金秉雲
  11. 中醫內科辨證學 王賢明
  12. 東醫處方學 東醫學硏究所 古典硏究室
  13. 東醫處方大全 東醫科學院
  14. 仲景全書 張仲景
  15. 醫門寶鑑 v.1 周命新
  16. 六科準繩(1) v.1 王肯堂
  17. 沈氏尊生書 v.12 沈金鱉
  18. 丹溪心法附與 朱震亨
  19. 神農本草經 吳普
  20. 神農本草經贊 葉志謀
  21. 本草撮要 張預
  22. 丹溪醫集 朱震亨
  23. 本草從新 李甲燮
  24. 醫學哀中參書錄 張錫純
  25. 景岳全書 張介賓
  26. 鄕藥集成方 科學百科辭典出版社
  27. 中和人民共和國藥典 中和人民共和國衛生部藥典委員會
  28. 中藥學 范聖第
  29. 中醫內科學 上海中醫學院
  30. 中醫臨床大全 楊思澍
  31. 慶熙韓醫大論文集 v.5 疎風湯 및 加味疎風湯 이 高脂血症에 미치는 影響 權寧哲(外)
  32. J. Pharma. Soc. Korea v.19 chemistry and pharmacology of diterpenoids of siegesbeckia pubescens Han, K.D.;Kim, J.H.;Oh, S.J.
  33. Shoyakugaku Zasshi v.39 Inhibition of metyrapone and heatstress induced hypertension by Phellodendti Cortex Kuauo, A.;Yasuo, O.;Jong-Chol, C.
  34. 부산대논문집 v.18 상기생의 순환기계 약리학적 연구 洪承喆
  35. 藥理學實驗法 田村風幸
  36. 藥效の評價(Ⅰ) 津田恭介;野上壽
  37. J. Pharm. Pharmacol. v.21 A perfused tail artery preperation from the rat Nicholas, T.E.
  38. J. Phamacol. Exp. Therap. v.225 Mouse antithrombotic assay : A simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by alcohol Dimino, G.;Silver, M.J.
  39. Pharmacology and Toxicology v.70 Antithrombotic activity of a new pyrazosine derivativedetermined by the mouse antithrombotic assay Petrusewiez, J.(et al.)
  40. Throm. Res. v.54 Role of free radicals in pulmonary thromboembolism in mice Dikshit, M.(et al.)
  41. Life Science v.51 A novel insight into the mechanism of the antithrombotic action of defibrotide Rosella, T.(et al.)
  42. Thrombosis and Hemostasis v.66 no.4 Antithrombotic effect of MCI-9042, a new antiplatelet agent on experimental thrombosis models Hara, H.(et al.)
  43. Tromb. Res. v.52 Comparison of hirudin and hirudin PAC-terminal fragments and related analogs as antithrombin agents Krstenansky, J.L.;Mao, S.J.T.
  44. Prostaglandins v.32 Effect of prostaglandins and arachidonic acid on baboon cerebral and mesenteric arteries Hayashi, S.;Park, M.K.
  45. Eur. J. Pharmacol. v.81 Comparison of the potencies of some prostaglandins as vasodilators in three vascular beds of the anaesthetised dog Lumley, P.(et al.)
  46. Thrombosis and Hemostasis v.3 Antithrombotic activity of a novel C-terminal hirudin analog in experimental animals Broersma, R.J.(et al.)
  47. J. Phsiol. v.168 the aggregation of blood platelets Born, G.C.R.;Cross, M.J.
  48. Thrombosis Res. v.65 TFC-612, a prostaglandin E1 derivative, enhance fibrolytic activity in rats Yukio Motoyama(et al.)
  49. Tromb. Hemostasis v.47 Effect of prostacyclin on fibrolytic activity in patients with arteriosclerosis obliterans Kiek, A.d.;Trabka, E.K.(et al.)
  50. Tromb. Haemostasis v.46 The effect of prostacyclin infusion on tissue plasminogen activator Winther, K.(et al.)
  51. Angiology v.35 The role of fibrinolysis in the therapy of peripheral vascular disease Ambrus, C.N.(et al.)
  52. 神經外科學 大韓神經外科學會
  53. 圖解腦神經外科學 郭隆璨
  54. 臨床神經診察法 金枓元