Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Stimulatory Effects of Ginsenoside-Rg1 on p56lck Kinase and Cell Proliferation in Jurkat T Cells

Jurkat T 세포에서 Ginsenoside-Rg1이 p561ck Kinase 활성과 세포증식에 미치는 영향

  • Hong, Hee-Youn (College of Pharmacy, Chonnam National University) ;
  • Na, Do-Seong (College of Pharmacy, Chonnam National University) ;
  • Kwon, Tae-Ik (Department of Biochemistry, Chungnapn National University) ;
  • Choi, Jung-Kap (College of Pharmacy, Chonnam National University) ;
  • Yoo, Gyurng-Soo (College of Pharmacy, Chonnam National University)
  • Published : 1995.08.01
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Abstract

We studied the effects of ginsenoside-$Rg_1$ (G-$Rg_1$) extracted from Panax ginseng C.A. Meyer on $p56^{kk}$ kinase and cell proliferation in Jurkat T cells. $p56^{kk}$ was maximally activated within 5 min after the treatment of 16.7 $\mu\textrm{g}$/ml of G-$Rg_1$ increasing the activity by 1.2-2 times relative to untreated control, thereafter its activity was gradually decreased to the level of untreated control. The action of EGTA on the kinase was altered by the addition of G-$Rg_1$, accompanying the band shift of $p56^{kk}$ to $p60^{kk}$. In addition, G-$Rg_1$promoted cell proliferation in a concentration-dependent manner. These results suggest that G-$Rg_1$ may be involved in T cell receptor-CD3 (TCR) signaling via the activation of $p56^{kk}$ and the chance of cellular calcium concentration.

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