Toxicological Research

  • 제12권1호
  • /
  • Pages.9-15
  • /
  • 1996
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

흰쥐 간의 microsomal enzymes의 유도에 있어서 benzene, toluene과 xylene의 복합적인 영향과 그들의 대사산물

Combinatory Effects of Benzene, Toluene and Xylene on the Induction of Rat Liver Microsomal Enzymes and Their Metabolites

  • 김기웅 (한국산업안전공단 산업보건연구원) ;
  • 박상신 (한국산업안전공단 산업보건연구원) ;
  • 김태균 (한국산업안전공단 산업보건연구원) ;
  • 문영한 (한국산업안전공단 산업보건연구원) ;
  • 장성근 (순천향대학교 자연대 화학과)
  • 발행 : 1996.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

We studied the effects of a single, combined and mixed exposure of benzene, toluene and xylene on the activities of rat liver microsomal AHH, ADH and ALDH, and the excretion of their metabolites in urine. The AHH activities of the rats treated in combination and mixture were slightly higher and/or similar to those rats treated with single solvent, while the reverse effects were observed for ADH and ALDH. Similar effects were observed when the metabolites were examined in urine (p < 0.01). These results suggest that each solvent might interJkre the induction and action of ADH and ALDH, and decrease the excretion of their metabolites into urine.

키워드

참고문헌

  1. 한국산업위생학회 v.4 Trichloroethylene 처리한 흰쥐의 간 미크로좀 Alcohol dehydrogenase와 Aldehyde dehydrogenase 활성도에 관한 연구 김기웅;강성규;양정선;박인정;문영한
  2. 예방의학회지 v.28 Ethanol이 Trichloroethylene 대사효소의 활성도와 유도성에 미치는 영향 김기웅;강성규;조영숙;이세휘;문영한;최병순;박상신
  3. 한국독성학회지 v.11 Cytochrome P-450 의존성 radical 전달에 의한 Benzene, Tolene, Xylene의 대사기전 연구 김기웅;장성근;김양호;문영한
  4. American Conference of Governmental Industrial Hygienists Documantation of the threshold limit values and biological exposure indices. 5th. ACGIH
  5. Threshold Limit Values (TLVs) for Chemical Substances and Physical Agents and Biological Exposure Indices (BEIs) ACGIH
  6. Solvent neurotoxicity Arlien-Soborg,P.
  7. Biomedical Pubrication Biological monitoring methods for industrial chemicals Baselt,R.C.
  8. Methods in Enzymology. v.78 Liver alcohol dehydrogenase Bonnichsen,R.K.;Brink,N.G.
  9. Mol. Pharmacol. v.1 Metabolism of trichloroethylene in liver microsome. II. Identification of the reaction products as chloral hydrate Byngton,K.H.;Leibman,K.C.
  10. J. Ind. Med. v.48 Exposure to mixtures of solvents among paint workers and biochemical alterations of liver function Chen,J.D.;Wang,J.D.;Jang,J.P.;Chen,Y.Y.
  11. Scand. J. work. Environ. Health. v.5 Toluene. a toxicology review. Cohr,K.H.;Stokholm,J.
  12. Int. Arch. Arbeitsmed. v.33 Reciprocal metabolic inhibition of toluene and trichloroethylene in vivo and in vitro Ikeda,M.
  13. Xenobiotica v.2 In vivo suppression of benzene and styrene oxidation by co-administered toluene in rats and effects of phenobarbital. Ikeda,M.;Ohtsuji,H.;Imamura,T.
  14. Scand. J. Work Environ. Health. v.12 Experimental exposure to toluene in combination with ethanol intake Iregren,A.;Akerstedt,T.;Olson,B.A.;Gamberale,F.
  15. J. Biol. Chem. v.193 Protein measurment with folin phenol reagent Lowry,O.H.;Rosebrough,N.J.;Farr,A.L.;Randall,R.J.
  16. Biochem. Pharmacol. v.28 Quantitative correlation of ethanol elimination rates in vivo with liver alcohol dehydrogenase activities in fed, fasted adn food-restricted rats Lumang,L.;Bosron,W.F.;Li,T.K.
  17. Br. J. Ind. Med. v.47 Exposure to toluene increases the urinary excretion of D-glucaric acid Moretto,A.;Lotti,M.
  18. Toxicol. Appl. Pharmacol. v.94 Ethanol- induced enhancement of trichloroethylene metabolism and hepatotoxicity: Difference from the effect of phenobarbital Nakajima,T.;Okino,T.;Okuyama,S.;Kaneko,T.;Yonekura,I.;Sato,A.
  19. Int. Arch. Occup. Environ. Health. v.65 Immunochemical assesment of the influence of nutritional, physiological and environmental factors on the metabolism of toluene Nakajima,T.;Wang,R.S.;Murayama,N.
  20. J. Biol. Chem. v.234 Substrate inducible microsomal aryl hydrocarbon hydroxylase in mammalian cell culture. I. Assay and properties of the induced enzymes Nebert,D.W.;Gelboin,H.V.
  21. Ann. Rev. Biochem. v.56 P450 Gene. Structure, evoluation and regulation Nebert,D.W.;Gonzalez,F.J.
  22. Int. Arch. Occup. Environ. Health. v.39 Quantitative determination of urinary HA and m-or p-xylene exposure by HPLC Ogat,M.;Sugihara,R.;Kira,S.
  23. Toxicol. Appl. Pharmacol. v.108 Morphological and biochemical analyses of trichloroethylene hepatotoxicy: Differences in ethanol-, and phenobarbital- pretreated rats Okino,T.;Nakajima,T.;Nakano,M.
  24. J. Biol. Chem. v.239 The carbon monoxide binding pigment of liver microsomes. I. Evidence for its hemoprotein natural Omura,T.;Sato,R.
  25. Korean Biochem. J. v.17 Induction of the different forms cytochrome P-450 isozymes and comparison of aryl hydrocarbon hydroxylase levels on rat tissues by chemical treatment Park,K.H.;Kim,C.R.
  26. Biochem. J. v.54 Studies in detoxication. The metabolism of benzene containing 14C-benzene Park,D.V.;Williams,R.T.
  27. Toxicol. Appl. Pharmacol. v.82 A comparative study of the effects of benzene, toluene, and xylenes on their in vivo metabolism and drug-metabolizing enzymes in rat liver Pathiratne,A.;Puyear,R.L.;Brammer,J.D.
  28. Toxicol. Ind. health. v.9 Liver function in rats treated individually and with a combination of xylene, toluene and methanol Rana,S.V.C.;Kumar,S.
  29. Scand. J. Work Environ. Health. v.5 Conjugation and urinary excretion of toluene and m-xylene metabolites in a mam Riihimaki,V.
  30. J. Pharmaceut. Sci. v.80 In vitro interaction between psychotropic drugs and alcohol dehydrogenase activity Roig,M.G.;Bello,F.;Burguillo,F.J.;Cachaza,J.M.;Kennedy,J.F.
  31. Toxicol. Appl. Pharmacol. v.99 Effect of exposure concentrations, exposure rats, and route of administration on metabolism of benzene by F344 rats and B6C3F1 mice Sabourin,P.J.;Bechtold,W.E.;Griffith,W.C.;Birnbaum,L.S.;Lucier,G.;Henderson,R.F.
  32. Toxicol. Appl. Pharmacol. v.48 Dose-dependent metabolic interaction between benzene and toluene in vivo and in vitro Sato,A.;Nakajima,T.
  33. Acta. Pharmacol. Toxicol. v.46 Combined effects of xylene and alcohol on the central nervous system Savolainen,K.
  34. J. Biochem. v.98 Biogenesis of microsomal aldehyde dehydrogenase Takagi,Y.;Ito,A.;Omura,T.
  35. Biochem. J. v.135 The Subcellular Distribution and Properties of Aldehyde Dehydrogenase in Rat Liver Tottmar,S.O.C.;Pettersson,H.;Kiessling,K.H.
  36. Toxicol. Appl. Pharmacol. v.59 Toxic effects of benzene and benzene metaboles on granulopoietic stem cells and bone marrow cellularity in mice Tunek,A.;Olofsson,T.;Berlin,M.
  37. Environ. Health. Criteria., Toluene v.52 International programme on chemical safety World Health Organization
  38. Int. Rev. Physiol. v.21 Ethanol metabolism Khanna,J.,M.;Israel,Y.