한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제24권5호
  • /
  • Pages.591-596
  • /
  • 1996
  • /
  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Polyozellus multiplex가 생산하는 지질괴산화 저해물질

  • 황지숙 (한국과학기술연구원 생명공학연구소) ;
  • 송경식 (경북대학교 농화학과) ;
  • 김양섭 (농촌진흥청 농업과학기술원) ;
  • 석순자 (농촌진흥청 농업과학기술원) ;
  • 이태호 (부산대학교 미생물학과) ;
  • 유익동 (한국과학기술연구원 생명공학연구소)
  • 발행 : 1996.10.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

In the course of screening lipid peroxidation inhibitor from basidiomycetes, a mushroom, which was collected at O-Dae mountain in Kangweon- Do, was found to have active compound. The mushroom was identified as Polyzellus multiplex, which belongs to Aphylloporalles Thelephoraceae, on the basis of macroscopic and microscopic characteristics of the fruiting body. The methanol extract of fruiting body was extracted with benzene and ethylacetate, sequentially. By using various kinds of chromatographies, PM1, and PM2 and PM3, were purified from the ethylacetate extract and the benzene extract, respectively. Color reaction and analyses of IR, UV, and NMR spectra indicated that PM1 was a derivative of thelephoric acid, and PM2 and PM3 were linoleic acid and oleic acid, respectively. IC$_{50}$ of PM1 for inhibition of lipid peroxidation was 1.96 ppm and LD$_{50}$ was 500 mg/kg.

키워드

참고문헌

  1. Carbohyd. Res. v.186 Fractionation and antitumor activity of the water insoluble residues of Agricus blazei fruiting bodies. Kawagishi,H;R.Inagaki;T.Kanao;T.Mizuno;K.Shimura;H.Ito;T.Hagiwara;T.Nakamura.
  2. Chem. Pharm. Bull. v.33 The biologically active constituents of Ganoderma lucidum (FR) KARST. Histamine release-inhibitory triterpenes. Kohda,H;W.Tokumoto;K.Sakamoto;M.Fujii;Y.Hirai;K.Yamasaki;Y.Komoda;H.Nakamura;S.Isohihara;M.Uchida.
  3. Planta Med. v.55 Hypoglycemic actions of some heteroglycans of Ganoderma lucidum fruit bodies. Hikino,H;T.Mizuno.
  4. Agric. Biol. Chem. v.54 Structural Characterization of the immunoactive and Antiviral Water-solubilized Lignin in an Extract of the Culture Medium of Lentius edodes Mycelia (LEM). Suzuki,H;K.Iiyama;O.Yoshida;S.Yamazaki;N.Yamamoto;S.Toda.
  5. Biochim. Biophysics. Acta. v.316 Lipids of human atheroma Ⅷ, Oxidised derivatives of cholesteryl linoleate. Harland,W.A;J.D.Gilbert;C.J.W.Brooks.
  6. Cli. Sci. v.66 Lipid peroxidation on rheumatoid arthritis:thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients. Rowley,D;J.M.C.Gutteridge;D.Blake;M.Farr;B.Halliwell.
  7. J. Am. Oil. Chem. Soc. v.52 Toxicology and biochemistry of butylated hydroxy anisole and butylated hydroxy toluene. Branen,A.L.
  8. Macroscopic features How to identify mushrooms to genus I. Largent,D.L.
  9. Micorscopic features, 2) Laboratory techniques. How to identify mushrooms to genus Ⅲ. Largent,D.L.
  10. Ladd Research Industries Biological techniques for Transmission and Scanning Electron Microscopy, Clinton J.D
  11. Anal. Biochem. v.95 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction. Ohkawa,H;N.Ohish;K.Yagi.
  12. Mycologia v.39 The Cantharellus in the Western United States. Alexander,H.S;E.M.Elizabethe.
  13. Mycology v.70 The Cantharelloid fungi of new England and adjacent areas. Bigelow,H.E.
  14. 농업기술연구소 굴뚝버섯과 한국산 버섯류 원색도감(Ⅰ) 농촌진흥청
  15. Colored illustrations of mushrooms of Japan v.Ⅱ Thelephoraceae Imazeki R;T.Hongo.
  16. A monograph of Cantharelloid fungi Cantharellus Corner,E.J.H;F.R.S.Corner;F.L.S.Corner
  17. Tetrahedron v.10 Fungus pigments-XII, The structure and synthesis of thelephoric acid. Gripenberg,J.
  18. The Aldrich library of /sup13/C and/sup1/H FT NMR spectra. v.Ⅰ Charles,J.Pouchert;Behnke,J.
  19. J. Natural Products. v.56 Structure of Benthophoenin, a new free radical scavenger produced by Streptomyces prunicolor. Shin-ya K;Y.Hayakawa;H.Seto.