Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Short-Term Feeding of Dietary Fiber Supplements on Glucose Metabolism in Subjects with Non-Insulin-Dependent Diabetes Mellitus

단기간의 식이섬유 첨가물의 섭취가 인슐린 비의존성 당뇨병 환자의 당질대사에 미치는 영향

  • 이연경 (경북대학교 식품영양학과) ;
  • 이혜성 (경북대학교 식품영양학과) ;
  • 김보완 (경북대학교 의과대학 내과학교실)
  • Published : 1996.10.01
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Abstract

High dietary fiber(DF) diets lower blood glucose and insulin requirements in diabetics. In this study we evaluated the effects of high dietary fiber(DF) food supplements on glucose metabolism in thirty-four subjects with non-insulin-dependent diabetes mellitus(NIDDM). The subjects were divided into three test groups. Each group's prescribed hospital diets were augmented by one of the three following DF supplements for two weeks: Soybean biscuits containing 5g of total DF-the control group(n=15); Biji biscuits containing 20g of total DF-the high insoluble DF group(n=9); and sea tangle biscuits containing 25g of total DF-the high soluble DF group(n=10). The mean daily DF intake of the subjects during the period were: $19.1\pm4.3g$ for the soybean control group; $32.5\pm4.1g$ for the Bijl group; and $38.1\pm5.5g$ for the sea tangle group. The supplementation of the Biji or sea tangle biscuits singnificantly lowered fasting serum glucose levels(p < 0.05) and resulted in the improvement of glucose tolerance. However, the secretions of insulin, C-peptide, and glucagon and Hb $A_{lc}$ concentration were not affected by the high fiber supplementary feeding for two weeks. The urinary excretion of glucose decreased remarkably after the addition of the DF supplements in all three groups(p<0.05). The results indicate that the supplementation of Biji or sea tangle bascuits possesses a beneficial effect on the improvement of glucose metabolism in subjects with NIDDM.

인슐린 비의존성 당뇨병 환자를 대상으로 식이섬유 섭취량을 증가시키기 위한 방법으로서 병원에서 처방된 식사에 더하여 일일 5g의 식이섬유를 포함하는 콩가루 비스켓(15명, 대조군), 20g을 포함하는 비지 비스켓(9명 , 불용성 고식이섬유군) 또는 25g을 포함하는 다시마 비스켓(10명, 수용성 고식이섬유군)을 2주 동안 첨가 섭취시킨 후 당질대사 개선효과를 평가하였다. 실험기간 중 당뇨병 환자들의 일일 열량 섭취량은 세군간에 유의한 차이가 없었고, 하루 실제로 섭취한 평균 총 식이섬유량은 대조군이 $19.1\pm4.3g(13.8\pm8.0g/1000kca1),$ 비지 비스켓군이 $32.5\pm4.1g(19.7\pm3.8g/1000kcal),$ 다시마 비스켓군이 $38.1\pm5.5g(24.5\pm4.5g/1000kcal)이었다.$ 비지 비스켓과 다시마 비스켓의 2주간 섭취 후 공복시 고혈당의 하강폭이 대조군에 비해 유의하게 컸으며 (p<0.05), 경구 포도당 부하 후의 내당능도 뚜렷하게 개선되었다(p<0.05). 경구 포도당 부하검사 및 글루카곤 자극검사를 통해 관찰한 바 혈청 인슐린과 C-peptide 수준 및 혈장 글루카곤의 농도는 2주간의 고식이섬유 첨가물의 섭취에 의해 변화를 보이지 않았다. 당화혈색소 수준은 2주간의 식이 섬유 첨가물 섭취 후에 다소 감소 경향을 보였으나 유의한 변화로는 판정되지 않았고 일일 요당의 배설량은 세군 모두에서 비스켓 섭취전에 비해 유의하게 감소되었다(p<0.05). 2주 동안의 식이섬유 첨가 섭취가 인슐린 비의존성 당뇨병 환자의 당질대사에 긍정적인 효과를 미치는 것으로 관찰되었으므로 비지와 다시마 첨가물이 당뇨병의 식사요법에서 유용한 고식이섬유 식품 첨가물로서의 가능성이 있는 것으로 판단된다.

Keywords

References

  1. Diabetes v.24 Dietary-fiber hypothesis of the etiology of diabetes mellitus Trowell, H. C.;Woodgreen, M. D.
  2. Am. J. Clin. Nutr. v.32 High-carbohydrate, high-fiber diets fro insulin-treated men with diabetes mellitus Anderson, J. W.;Ward, K.
  3. Dietary fiber : Basic and clinical aspects Dietary fiber in nutrition management of diabetes Anderson, J. W.;Vahouny, G. V.(ed.);Kritchevsky, D.(ed.)
  4. J. Am. Diet. Assoc. v.85 Adherence to high-carbohydrate, high-fiber diets: Long-term studies of non-obese diabetic men Story, L.;Anderson, J. W.;Chen, W-J. L.
  5. Can. Med. Assoc. J. v.123 Hihg-fibre diets for diabetic and hypertriglyceridemic patients Anderson, J. W.
  6. Diabetes Care v.14 Dietary fiber-An overview Anderson, J. W.;Akanji, A. O.
  7. Diabetes Care v.10 Nutritional recommendations and principles for individuals with diabetes mellitus American Diabetes Association
  8. Diabetes Educator v.9 The nutritional therapy of non-insulin dependent(type II) diabetes Crapo, P.
  9. Am. J. Med. v.85 New perspectives in nutrition management of diabetes mellitus Anderson, J. W.;Geil, P. B.
  10. 당뇨병 v.18 인슐린 비의존성 당뇨병 환자의 식이섬유 섭취실태 이연경;이혜성;김보완
  11. 한국영양학회지 v.27 한국인의 식이섬유 섭취상태의 연차적 추이(1969~1990) 이혜성;이연경;서영주
  12. Am. J. Clin. Nutr. v.48 Low glycemic index starchy foods in the diabetic diet Jenkins, D. J. A.;Wolever, T. M. S.;Buckley, G.;Lam, K. Y.;Giudici, S.;Kalmusky, J.;Jenkins, A. L.;Patten, R. L.;Bird, J.;Wong, G. S.;Josse, R. G.
  13. Am. J. Clin. Nutr. v.38 Factors affecting starch digestibility and the glycemic response with special reference to legumes Thorne, M. J.;Thompson, L. U.;Jenkins, D. J. A.
  14. Am. J. Clin. Nutr. v.54 Glycemic response and fiber content of some foods Nishimune, T.;Yakushiji, T.;Sumimoto, T.;Taguchi, S.;Konishi, Y.;Nakahara, S.;Ichikawa, T.;Kunita, N.
  15. J. Sci. Food Agric. v.54 Marine algae as sources of fibers : Determination of soluble and insoluble dietary fibre contents in some "sea vegetables' Lahaye, M.
  16. Handbook of water-soulble gums and resins Davison, R. L.
  17. J. Nutr. v.121 A small dose of soluble alginate-fiber effects postprandial glycemia and gastric empbying in humans with diabetes Torsdottir, I.;Alpstrn, M.;Goran, H.;Sandberg, A. S.;Tolli, J.
  18. J. Jpn. Soc. Nutr. Food Sci. v.43 Effect of a dietary fiber-protein mixture on glucose tolerance and lipid metabolism on diabetics Watanabe, Y.;Kawai, K.;Yamashita, K.
  19. 당뇨병 v.19 단기간의 식이섬유 첨가물의 섭취가 인슐린 비의존성 당뇨병 환자의 지질대사에 미치는 영향 이연경;이혜성;김보완
  20. 한국영양학회지 v.24 대학생의 식이섬유 섭취에 관한 연구 이혜성;이연경;Shirley, C. Chen
  21. SPSS/$PC^+$를 이용한 통계분석 채서일;김범종
  22. Am. J. Clin. Nutr. v.37 Long-term effect of dietary fiber on glucose tolerance and gastric emptying in noninsulin-dependent diabetic patients Ray, T. K.;Mansell, K. M.;Kinght, L. C.;Malmud, L. S.;Owen, O. E.;Boden, G.
  23. Am. J. Clin. Nutr. v.48 GI transit and absorption of soild food : Multiple effects of guar Meyer, J. H.;Doty, J. E.
  24. Clin. Sci. v.66 The mechanism of action of guar gum in improving glucose tolerance in man Blackburn, N. A.;Redfern, J. S.;Jarjis, H.;Holgate, A. M.;Hanning, I.;Scarpello, J. H. B.;Johnson, I. T.;Read, N. W.
  25. Gut v.22 Effect of gel forming gums on the intestinal unstirred layer and sugar transport in vitro Johnson, I. T.;Gee, J. M.
  26. Gut v.25 Effect of pectin on jejunal glucose absorption and unstirred layer thickness in normal man Flourie, B.;Vidon, N.;Florent, C. H.;Bernier, J. J.
  27. Diabetes Care v.7 Effect of a high-starch diet with low or high fiber content on postabsorptive glucose utilization and glucose production in normal subjects Nestel, P. J.;Nolal, C.;Bazelmans, J.;Cook, R.
  28. Metabolism v.32 Increased insulin binding to adipocytes and monocytes and increased insulin sensitivity of glucose transport and metabolism in adipocytes from non-insulin-dependent diabetics after a low fat/high starch/high fiber diet Hjollund, E.;Pederson, O.;Richelsen, R.;Beck-Nielsen, H.;Sorenen, N. S.
  29. Diabetes Care v.5 Increased insulin receptor binding to monocytes from insulin-dependent diabetic patients after a low-fat, high-starch, high-fiber diet Pederson, O.;Hjollund, E.;Lindskov, H. O.;Helms, P.;Sorensen, N. S.;Ditzal, J.
  30. J. Lipid Res. v.18 Comparison of insulin binding by liver plasma membranes of rats fed a high glucose diet or a high fat diet Sun, J. V.;Tepperman, H. M.;Tepperman, J. A.
  31. Eur. J. Clin. Invest. v.12 Insulin receptor binding increased by high carbohydrate low fat diet in noninsulin dependent diabetics Ward, G. M.;Simpson, R. W.;Simposn, H. C. R.;Naylor, B. A.;Mann, J. I.;Turrner, R. C.
  32. Am. J. Physiol. v.237 Glucose clamp technique : A method of quantifying insulin secretion and resistance DeFronzo, R. A.;Tobin, J. D.;Andres, R.
  33. Metabolic effects of utilizable dietary fiber carbohydrate High-carbohydrate diet effects on glucose and triglyceride metabolism of normal and diabetic men Anderson, J. W.;Reiser, S.(ed.)
  34. Diabetologia v.17 The effects of unabsorbable carbohydrate on gut hormones Morgan, L. M.;Golulder, T. J.;Tsiolakis, D.;Marks, V.;Alberti, K. G. M. M.
  35. Diabetes Care v.3 Glucose tolerance and blood lipids in bran-fed patients with impaired glucose tolerance Bosello, O.;Ostuzzi, R.;Armellini, R.;Micciolo, R.;Scuro, L. A.
  36. Am. J. Clin. Nutr. v.51 Relationship between dietary fiber content and composition in foods and the glycemic index Wolever, T. M. S.
  37. Am. J. Clin. Nutr. v.54 Glycemic response and fiber content of some foods Nishimune, T.;yakushiji, T.;Sumimoto, T.;Taguchi, S.;Konishi, Y.;Nakahara, S.;Ichikawa, T.;Kunita, N.
  38. Am. J. Clin. Nutr. v.48 Low glycemic index starchy foods in the diabetic diet Jenkins, D. J. A.;Wolever, T. M. S.;Buckley, G.;Lam, K. Y.;Giudici, S.;Kalmusky, J.;Jenkins, A. L.;Patten, R. L.;Bird, J.;Wong, G. S.;Josse, R. G.
  39. Diabetes Care v.13 Glucose toxicity Rossetti, L.;Giaccari, A.;DeFronzo, R. A.
  40. Diabetologia v.28 Hyperglycemia as an inducers as well as consequence of impaired islet cell function and insulin resistance : Implications for the management of diabetes Unger, R. H.;Grundy, S.
  41. Diabetes v.38 Type II diabetes, glucose "non-sense" and islet desensitization Robertson, R. P.
  42. Diabetes v.33 Impaired insulin action in rats with non-insulin-dependent diabetes Levy, J.;Gavin, J. R.;Fausto, A.;Gingerich, R. L.;Avioli, L. V.
  43. Metabolism v.34 Hepatic and peripheral insulin deficiency in the dog Bevilacqua, S.;Barrett, E. J.;Smith, D.;Simonson, D. C.
  44. Diabetologia v.13 Development of insulin resistance in normal dogs following allozan-induced insulin deficiency Reaven, G. M.;Sageman, W. S.;Swenson, R. S.
  45. J. Clin. Invest. v.79 Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats Rosetti, L.;Smith, D.;Shulman, G. I.;Papachristiou, D.;DeFronzo, R. A.
  46. Diabetes v.36 Hyperglycemia decrease glucose uptake in typeⅠdiabetes Yki-jarvinen, H.;Helve, E.;Koivisto, V. A.
  47. Lancet v.1 The essential role of glucagon in the pathogenesis of the endogenous in the hyperglycemia of diabetes mellitus unger, R. H.;Orei, L.
  48. Diabetologia v.17 The effects unabsorbable carbohydrate on gut hormones Morgan, L. M.;Goulder, T. J.;Tsiolakis, D.;Marks, V.;Alberti, K. G. M. M.
  49. Ann. Intern. Med. v.88 High fiber diet in the treatment of diabetes mellitus Miranda, P. M.;Horwitz, D. L.
  50. Am. J. Clin. Nutr. v.45 Effect of soy polysaccharide on postprandial plasma glucose, insulin, glucagon, pancreatic polypeptide, somatostatin and triglyceride in obese diabetic patients Tsai, A. C.;Vinik, A. I.;Lasichak, A.
  51. Japan Diabe. Soc. v.23 Treatment of diabetes mellitus with glucomannan Matsuara, M.;Hirose, Y.;Kawara, A.;Saminoe, K.;Takeda, F.;uenoyama, R.;Doi, K.;Baba, S.;Nishikawa, K.