생약학회지 (Korean Journal of Pharmacognosy)
- 제28권4호
- /
- Pages.174-178
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- 1997
- /
- 0253-3073(pISSN)
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- 2288-9299(eISSN)
약용 식물의 암세포 다제내성 조절 활성 검색
Multidrug-resistance Reversing Activity of Medicinal Plants
- Kim, Se-Eun (Natural Product & Biosynthesis R.U, Korea Research Institute of Bioscience and Biotechnology) ;
-
Hwang, Bang-Yeon
(Natural Product & Biosynthesis R.U, Korea Research Institute of Bioscience and Biotechnology)
;
-
Kim, Young-Ho
(Natural Product & Biosynthesis R.U, Korea Research Institute of Bioscience and Biotechnology)
;
- Kim, Young-Choong (College of Pharmacy, Seoul National University) ;
-
Lee, Kyong-Soon
(College of Pharmacy, Chungbuk National University)
;
- Lee, Jung-Joon (Natural Product & Biosynthesis R.U, Korea Research Institute of Bioscience and Biotechnology)
- 발행 : 1997.12.30
초록
Methanol extracts from 450 plants were screened for muttidrug-resistance reversing activity using drug sensitive KB-3-1 and multidrug-resistant KB-Vl cells. Among them, the extracts of Cynanchum wilfordii, Torilis japonica, Celastrus orbiculatus, Melia toosendan and Teminialia chebula strongly potentiated vinblastine cytotoxicity in KB-Vl cells. But their cytotoxicities to both sensitive KB-3-1 and resistant KB-Vl cells were in the same order of magnitude. These results indicate that the above samples would contain the active principles which do not exert their ativity solely by cytotoxicity.
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