The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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The Effect of Sohabhyangwon(蘇合香元) on Regional Cerebral Blood Flow and Area of Cerebral Infarction in the Experimentally induced Cerebral Infarction in Rats

소합향원(蘇合香元)이 실험적(實驗的) 뇌경색(腦梗塞) 흰쥐의 국소뇌혈류량(局所腦血流量) 및 경색(梗塞) 면적에 미치는 영향(影響)

  • Choi, Eun-Jeong (Dept. of Internal Medicine College of Oriental Medicine Dongguk University) ;
  • Shin, Gil-Cho (Dept. of Internal Medicine College of Oriental Medicine Dongguk University) ;
  • Lee, Won-Chul (Dept. of Internal Medicine College of Oriental Medicine Dongguk University)
  • 최은정 (동국대학교 한의과대학 내과학 교실) ;
  • 신길조 (동국대학교 한의과대학 내과학 교실) ;
  • 이원철 (동국대학교 한의과대학 내과학 교실)
  • Published : 1997.04.30
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Abstract

The cerebral infarction arised from occulsion of cerebral artery has a high mortality rate and fatal sequelae. Sohabhyangwon(蘇合香元) is generally regarded to have a effect of walking up the patient from unconsiousness and promoting the flow of Qj(氣) by warming channel. METHOD The purpose of this study is to find out the effections of Sohabhyangwon(蘇合香元) on regional cerebral blood flow and relative cerebral infarction area in the experimentally induced infartion in rats In this experiment, 12 Spraque-Dawley rats weighting 280-350g were used. Cerebral ischemia induced by intraluminal suture technique of Kozumi's and Zea-Longer's method. $Co_{2},\;O_2$, pH, arterial blood pressure in rats were checked by Blood Gas Analyzer every 30 minutes for 2 hours. And regional cerebral blood flow were checking by hydrogen clearance technique, cerebral infarcted area was megsured by Image Analysis System. RESULTS 1. During the experiment, $CO_{2},\;O_2$, pH, arterial blood pressure in rats had no change in both sample group and control group. 2. Cortical cerebral blood flow decreased at same rate in both sample group and control group after inducing cerebral infarction. 3. On comparison of relative cerebral infarcted area, Sohabhyangwon(蘇合香元) perfused group showed a significant decrease. CONCLUSION According to the result above, Sohabhyangwon has a protection effect on cranial nerve and-has no effect on cerebral blood flow.

Keywords

References

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