대한한의학회지 (The Journal of Korean Medicine)

  • 제18권1호
  • /
  • Pages.316-325
  • /
  • 1997
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  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

즉시형(卽時型) 알레르기 반응(反應)에 있어서 물추출액(抽出液)의 억제작용기전(抑制作用機轉)

Mechanism of Inhibitory Action of Anaphylaxis by Aqueous Extract of Poncirus trifoliata

  • 황광호 (원광대학교 한의과대학 내과학 교실) ;
  • 이언정 (원광대학교 한의과대학 내과학 교실) ;
  • 송봉근 (원광대학교 한의과대학 내과학 교실) ;
  • 김형균 (원광대학교 한의과대학 내과학 교실)
  • Hwang, Gwang-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Won kwang University) ;
  • Lee, Eon-Jeong (Dept. of Internal Medicine, College of Oriental Medicine, Won kwang University) ;
  • Song, Bong-Keun (Dept. of Internal Medicine, College of Oriental Medicine, Won kwang University) ;
  • Kim, Hyeong-Kyun (Dept. of Internal Medicine, College of Oriental Medicine, Won kwang University)
  • 발행 : 1997.04.30
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초록

The dried unripe fruit of Poncirus trifoliata L. is widely used to treat urticaria, itch and indigestion in folk medicine. And recently it was reported the component of the fruit was found to exhibit an inhibitory effect on histamine release from mast cells. So to evaluate the effect of aqueous extract of Poncirus trifoliata L.(PTFE) on compound 48/80-induced histamine release, the study was carried out in rat peritoneal mast cell. PTFE $(10^{-3}{\sim}1mg/ml)$ inhibits the histamine release induced by compound 48/80 $(5{\mu}g/ml)$ in rat peritoneal mast cells. To clarify the mechanism of these inhibition, we investigated the effect of PTFE on cAMP and intracellular calcium content. The increase in cAMP content, when PTFE was added, was transient. At concentration of 1mg/ml, the cAMP content of mast cells was significantly increased at a rate of 53 times of basal cells at 10sec. PTFE inhibits histamine release by augmenting the cAMP content in mast cells. Moreover, PTFE inhibits intracellular calcium release induced by compound 48/80. This result suggests that PTFE may be useful for the prevention and treatment of allergy-related disease.

키워드

참고문헌

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