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The Pharmaceutical Society of Korea (대한약학회)
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Ginseng Intestinal Bacterial Metabolite IH901 as a New Anti-Metastatic Agent

  • Hideo Hasegawa (Itto Institute of Life Science Research, Happy World Inc, Department of Pathogenic Biochemistry, Research Institute for Wakan-yaku) ;
  • Sung, Jong-Hwan (Central Research Institute, IL HWA Co. Ltd) ;
  • Huh, Jae-Doo (Central Research Institute, IL HWA Co. Ltd)
  • Published : 1997.12.01
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Abstract

Anti-metastatic activities of IH901, an intestinal bacterial metabolic derivative formed from Ginseng protopanaxadiol saponins, was determined in vitro and in vivo. Under in vitro conditions, IH901 inhibited the migration of bovine aortic endothelial cells 25 times stronger than suramin and suppressed the invasion of HT1080 human fibrosarcoma cells into reconstituted basement membrane components of Matrigel 1000 times stronger than RGDS peptide. IH901 also showed inhibitory effect on type-IV collagenase secretion from HT 1080 cells and platelet aggregation. When the anti-metastatic activity of IH901 was evaluated in comparison with that of 5-FU using a spontaneous lung metastatic model of Lewis lung carcinoma, the administration of IH901 (10 mg/kg p. o.) to tumor-bearing mice led to a significant decrease in lung metastasis (43% of untreated control), which was slightly more effective than that obtained with 5-FU (56% of control). Thus, IH901 seems to exhibit its anti-metastatic activity partly through the inhibition of tumor invasion which results from the blockade of type IV collagenase secretion and also through anti-platelet and anti-angiogenic activities.

Keywords

References

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