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The Pharmaceutical Society of Korea (대한약학회)
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Effects of Swainsonine on the Humoral Immune Response of Lipopolysaccharide

  • Published : 1997.12.01
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Abstract

Effects of swainsonine (SW;8${\alpha}$, ${\beta}$-indolizidine-${\alpha}$, $2{\alpha}$8-triol from Locoweed) on the humoral immune responses of lipopolysaccharide (LPS) wer studied in ICR mice. Mice were divided into 4 groups (10 mice/group), and LPS was given to each mouse 1 hr after i.p. injection with 3.7 mg/kg of swainsonine, by i.p. injection twice a week for 14 days at a dose of 2 mg/kg. Humoral immune responses were evaluated by hemagglutination (HA) titer and splenic plaque forming cells (PFC). The results of this study were summarized as follows: Mice administrated each of LPS and SW showed significant enhancement of the weight ratios of spleen to body, HA titer, 2-mercaptoethanol-resistant HA(MER-HA) titer and PFC compared with those in controls. However, the LPS plus SW treatment decreased HA titer, MER-HA titer and PFC corresponding to humoral immunity, as compared with those in the mice treated with LPS alone. These findings indicated that LPS significantly enhanced humoral immune responses, but their enhancement effects were lowered somewhat by SW.

Keywords

References

  1. J. Am. Chem. v.3 A short, enantioselective synthesis of (-) swainsonine Bennett,R.B.;Chai,J.R.;Montgomery,W.D.;Cha,J.K.
  2. Ann. Rev. Nutr. v.5 The indolizidine alkaloids, slaframine and swainsonine; Contaminants in animal forages Broquist,H.P.
  3. Proc. Natl. Acad. Sci. U.S.A. v.72 An endotoxin-induced serum factor that cause necrosis of tumors Carswell,E.A.;Old,L.J.;Kassel,R.L.;Green,S.;Fiore,N.;Williamson,B.
  4. J. Exp. Med. v.139 Mechanism of thymus-independent immunocyte triggering; Mitogenic activation of B cells results in specific immune responses Coutinho,A.;Gronowitz,E.;Bullock,W.W.;Mller,G.
  5. Immunology v.14 Futher improvements in the plaque technique for detecting single antibody forming cells Cunningham,A.J.;Szenberg,A.
  6. J. Natl. Cancer Inst. v.81 Inhibition of human HT 29 colon carcinoma growth in vitro and in vivo by swainsonine and human interferon-α₂ Dennis,J.W.;Koch,K.;Beckner,D.
  7. FASEB J. v.2 Biology of interleukin-1 Dinarello,C.A.
  8. Ann. Rev. Biochem. v.56 Inhibitors of the biosynthesis and processing of N-linked oligosaccharide chains Elbein,A.D.
  9. J. Biol. Res. Mod. v.9 Biological response to intravenously administered endotoxin in patients with advanced cancer Engelhardt,R.;Mackensen,A.;Galanos,C.;Andreesen,R.
  10. J. Exp. Med. v.157 Induction of murine autoimmune disease by chronic polyclonal B cell activation Hang,L.;Slack,J.H.;Amundson,C.;Izui,S.;Theofilopoulos,A.N.;Dixon,F.J.
  11. J. Antibiot. v.38 Studies of an immunomodulater, swain-sonine I; Enhancement of immune response by swainsonine in vitro Hino,M.;Nakayama,O.;Tsurumi,Y.;Adachi,K.;Shibata,T.;Terano,H.;Kohsaka,M.;Aoki,H.;Imanaki,H.
  12. Clin. Exp. Metast. v.8 Humphrise,M.J;Matsumoto,K.;White,S.L.;Molyneux,R.T.;Olden,K. An assessment of the effects of swainsonine on survival of mice injected with B16-F10 melanoma cells
  13. J. Antibiot. v.38 Studies of an immunomodulator, swain-sonine Ⅱ; Effect of swainsonine on mouse immuno-deficient system and experimental murine tumor Kino,T.;Inamura,N.;Nakahara,K.;Kiyoto,S.;Goto,T.;Terano,H.;Kohasaka,M.;Aoki,H.;Imanaka,H.
  14. Blood v.74 The biology of interleukin-6 Kishimoto,T.
  15. J. Pharmacol. Exp. Ther. v.96 Simplified method of evaluating dose-effect experiments Litchfield,J.T.;Wilcoxon,F.
  16. J. Immunol. v.147 Lipopolysaccharide responsiveness in an important factor in the generation of optimal antigen-specific T cell responses during infection with Gram-negative bacteria Marshell,N.E.;Ziegler,H.K.
  17. J. Immunol. v.122 Genetic control of in vivo sensitivity to lipopolysaccharide; Evidence for codominant inheritance McGhee,J.R.;Michalek,S.M.;Moore,R.N.;Mergenhagen,S.E.;Rosenstreich,D.L.
  18. Selected Methods in Cellular Immunology v.3 Preparation of mouse cell suspensions Mishell,B.B.;Shiigi,S.M.;Henry,C.;Chan,E.L.;North,J.;Gallily,R.;Slomich,M.;Miller,K.;Marbrook,J.;Parks,D.Good,A.H.;Mishell,B.B.(ed.);Shiigi,S.M.(ed.)
  19. Science v.216 Loco intoxication: indolizidine alkaloids of spotted locoweed (Astragalus lentiginosus) Molyneux,R.J.;James,L.F.
  20. Adv. Immunol. v.28 Bacterial endotoxins and host immune responses Morrison,D.C.;Ryan,J.L.
  21. Ann. Rev. Med. v.38 Endotoxins and disease mechanisms Morrison,D.C.;Ryan,J.L.
  22. J. Immunol. v.58 Divergent efffects of bacterial lipopoly-saccharide on immunity to orally administered protein and paticulate antigens in mice Mowat, A Mcl;Thomas,M.J.;Mackenzie,S.;Parrott,D.V.
  23. Cancer Res. v.49 Effect of swainsonine on stimulation of cell cycle progression of human lymphocytes Myc,A.;Kunicka,J.E.;Melamed,M.R.;Darzynkiewicz,A.
  24. Pharmac.Ther. v.50 The potential importance of swainsonine in therapy for cancers and immunology Olden,K.;Breton,P.;Grzegorzwski,K.;Yasuda,Y.;Gause,B.L.;Oredipe,O.A.;Newton,S.A.;White,S.L.
  25. J. Immunol. v.118 Lipopolysaccharide-induced suppression of the primary immune response to a thymus-dependent antigen Persson,U.
  26. B. Ssordeted . Karger Baselip Use of mast cell deficient mice to study host parasite relationships in immuno-deficient animals Reed,N.D.;Crowle,P.K.;Ha,T.
  27. J. Sci. American Bacterial endotoxins Rietschel,E.T.;Brade,H.
  28. Proc. Natl. Acad. Sci. U.S.A. v.85 Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice Rothstein,J.L.;Schreiber,H.
  29. J. Biol. Chem. v.262 Multiple effects of tumor necrosis factor on lipo-protein lipase in vivo Semb,H.;Peterson,J.;Tavernier,J.;Olivecrona,T.
  30. J. Clin. Immunol. Immunopathol. v.53 Endotoxin, tumor necrosis factor-α and interleukin-1 induce interleukin-6 production in vivo Shalaby,M.R.;Waage,A.;Aarden,L.;Espevik,T.
  31. J. Immunol. v.114 Immunologic properties of bacterial lipopolysaccharide (LPS); Correlation between the mitogenic, adjuvant and immunogenic activities Skidmore,B.J.;Chiller,J.M.;Morrison,D.C.;Weigle,W.O.
  32. J. Immunol. v.126 Macrophage-mediated tumor cell killing; Regulation of expression of cytolitic activity by prostaglandin E Taffet,S.M.;Russell,S.W.
  33. J. Biol. Chem. v.257 Swainsonine inhibits the biosynthesis of complex glycoproteins by by inhibition of Golgi mannosidase Ⅱ Tulsiani,D.P.;Harris,T.M.;Touster,O.
  34. See Ref. v.27 Locoweed poisoning in the United States Van Kampen, K. R.;Rhees,R.W.;James,L.F.
  35. Immunology v.38 Effect of stimuation and blockade of mononuclear phagocyte system on the delayed foot pad reation to SRBC in mice Yoshikai,Y.;Maike,S.;Matsumoto,T.;Nomoto,K.;Takeya,K.
  36. Ann. Pharmacother. v.25 Human monoclonal antibody against endotoxin Zarowitz,B.j.