Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지

Effect of Hormone Replacement Therapy on the Change of Pyridinoline from Bone and Cartilage Collagen of Ovariectomized Rats

호르몬 투여가 난소를 절제한 흰쥐의 골단백질 성숙에 미치는 영향

  • 김미향 (일본 오챠노미즈여자대학 식물과학과) ;
  • 유리나 (울산대학교 식품영양학과) ;
  • 하배진 (부산여자대학교 화학과) ;
  • 김상애 (부산여자대학교 식품영양학과) ;
  • 고진복 (부산여자대학교 생물학과)
  • Published : 1997.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

A decrease in the circulating levels of estrogen, occuring as a consequence of post menopausal decline or from surgical ovariectomy, results in an accelerated loss of bone. Estrogen has been shown to stimulate lysyl oxidase activity, and the treatment with estrogen increased the pyridinium content of cortical bone. a trivalent mature cross-links collagen fibrils named pyridinoline, which is especially abundant in collagen of cartilage and bone, markedly increases with growth in humans and rats. The main aim of this study was to examine the increased bone loss caused by ovariectomy through monitoring the concentrations of the collagen and the pyridinium cross-links of collagen, pyridinoline. The ovariectomized rats, 4 weeks old, were divided at random into two or three groups of 5. Ovariectomies were carried out on both of the saline-treated group(OVX(NH)) and the estrogen-treated group(OVX(H)) using the dorsal approach and sham operations were performed on the sham-operated group(sham). They were maintained under identical conditions for 4 or 8 weeks and were allowed free access to food and water. it was observed that there was no significant difference between the control group and the sham-operated group, however, the control group had a higher content of collagen than the saline-treated group after 4 weeks and 8 weeks. Based on these results, iot is supposed that estrogen can enhance collagen synthesis and affects the pyridinoline formation in collagen fibrils through stimulating lysyl oxidase activity.

Keywords

References

  1. 骨粗?症 松本俊夫
  2. J. Biologic. Chem. v.252 Collagen cross-linking effect of D-penicillamine on cross-linking in vitro Siegel, R. C.
  3. Biochem. J. v.163 The chemistry of the collagen cross-links Robins, S. P.;Bailey, A. J.
  4. 現代化學 v.8 コラ-ゲン分子の變化とエシング-老化をくいとめる方法はみつかるか 藤本大三郞
  5. Biochem. Biophys. Res. Commun. v.109 Aging and cross-linking in human aorta Fujimoto, D.
  6. Collagen in Health and Disease v.9 Turnover and cross-linking of collagen. Robins, S. P.
  7. Calcif. Tissue Int. v.34 Comparative molecular distribution of cross-links in bone and dentin collagen Kuboki, Y.;Mechanic, G. L.
  8. Biochem. Biophys. Res. Commun. v.152 Aging and cross-linking of skin collagen Yamauchi, M.;Woodley, D. T.;Mechanic, G. L.
  9. Biochem. J. v.252 Collagen cross-linking in human bone and articular cartilage Eyre, D. R.;Dickson, I. R.;Ness, K. V.
  10. J. Nutr. Sci. Vitaminol. v.40 Age-related changes in the pyridinoline content of guinea pigs cartilage and achilles tendon collagen Kim, M. H.;Otsuka, M.;Arakawa, N.
  11. J. Am. Med. Ass. v.116 Postmenopausal osteoporosis : its clinica features Albright, F.;Smith, P. H.;Richardson, A. M.
  12. J. Bone. Mineral Res. v.4 The effect of age and menopause on one mineral density of the proximal femur Hdund, L. R.;Gallagher, J. C.
  13. J. Cell Biol. v.113 Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro Yanaguchi, A.;Katagiri, T.;Ikeda, S.
  14. J. Cell. Biol. v.108 Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone Noda, M.;Rodon, G. A.
  15. コラ-グン代謝と疾患 永井裕;藤本大三郞
  16. J. Bone Min. Res. v.5 Changes with age in the urinary excretion of lysyl- and hydroxylysylpyridinoline, two new markers of bone collagen turnover Beardsworth, L. J.;Eyre, D. R.;Dickson, I. R.
  17. Calcif. Tissue. Int. v.44 Excretion of pyridinum cross-links of collagen in ovariectomized rats as urinary markers for increased bone resorption Black, D.;Farquharson, C.;Robins, S. P.
  18. Bone and Mineral v.18 Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease Uebelhart, D.;Gineyts, E.;Chapuy, M. C.;Delmas, P. D.
  19. Alcohol. Alcohol. v.26 The urinary excretion of the collagen degradation markers pyridinoline and deoxypyridinoline in an experimental rat model of alcoholic bone disease Preedy, V. R.;Sherwood, R. A.;Akpoguma, C. I. O.
  20. J. Clin. Endocrinol. Metab. v.72 Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links Uebelhart, D.;Schlemmer, A.;Johansen, J. S.;Gineyts, E.;Christiansen, C.;Delmas, P. D.
  21. J. Biochem. v.94 Analysis of pyridinoline, a cross-linking compound of collagen fibers, in human urine Fujimoto, D.;Suzuki, M.;Uchiyama, A.;Miyamoto, S.;Inove, T.
  22. Biochem J. v.197 Collagen cross linking compounds in human urine Gunja-Smith, Z.;Boucek, R. J.
  23. Biochem. Biophys. Res. Commun. v.101 Regulation of proryl and lysyl hydroxylase activities in cultured human skin fibroblasts by ascorbic acid Murad, S.;Sivarajah, A.;Pinnel, S. R.
  24. J. Nutr. Sci. Vitaminol. v.37 The behavior of L-ascorbic acid in the healing process of dorsal wounds in guinea pigs Yu, R.;Kurata, T.;Kim, M.;Arakawa, N.
  25. J. Vit. Nutr. Res. v.64 The distribution of ascorbic acid and dehydroascorbic acid during tissue regeneration in wounded dorsal skin of guinea pigs Kim, M.;Otsuka, M.;Yu, R.;Kurata, T.;Arakawa, N.
  26. J. Biochem. v.83 Phyridinoline, a nonreducible crosslink of collagen Fujimoto, D.;Moriguchi, T.
  27. Arch. Biochem. Biophys. v.93 The determination of hydroxyproline in tissue and protein samples containing small portions of this imino acid Woessner, J. F.
  28. J, Nutr. Sci. Vitaminol. v.38 An improved high-performance liquid chromatographic assay for the determination of pyridinoline in connective tissues Arakawa, N.;Kim, M. H.;Otsuka, M.
  29. J. Nutr. Sci. Vitaminol. v.40 Age-related changes in the pyridinoline content of guinea pigs cartilage and achilles tendon collagen Kim, M. H.;Otsuka, M.;Arakawa, N.
  30. J. Biochem. v.84 Age-related changes in the content of collagen crosslink, pyridinoline Moriguchi, T.;Fujimoto, D.
  31. Biochem. Biophys. Res. Commun. v.84 The structure of pyridinoline, a collagen crosslink Fujimoto, D.;Moriguchi, T.;Hayashi, H.
  32. Biochem. Biophys. Res. Commun. v.109 The structure of pyridinoline Barber, M.;Bordoli, R.;Elliott, G. J.;Fujimoto, D.;Scott. S. E.
  33. Biochem. Biophys. Res. Commun. v.104 Pyridinoline is a real moiety of collagen Tsuda, M.;Ogawa, T.;Kawamishi, Y.