Korean Journal of Food Science and Technology (한국식품과학회지)
- Volume 30 Issue 4
- /
- Pages.888-894
- /
- 1998
- /
- 0367-6293(pISSN)
Effect of Si-Wu-Tang and Si-Jun-Zi-Tang on the Survival of Jejunal Crypt Cells and Hematopoietic Cells in Irradiated Mice
방사선조사 마우스에서 소장움세포 및 조혈세포 생존에 미치는 사물탕 및 사군자탕의 영향
- Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University) ;
- Oh, Heon (College of Veterinary Medicine, Chonnam National University) ;
- Lee, Song-Eun (College of Veterinary Medicine, Chonnam National University) ;
- Jo, Sung-Kee (Department of Food Irradiation, KAERI) ;
- Byun, Myung-Woo (Department of Food Irradiation, KAERI)
- 김성호 (전남대학교 수의과대학) ;
- 오헌 (전남대학교 수의과대학) ;
- 이송은 (전남대학교 수의과대학) ;
- 조성기 (한국원자력연구소 방사선식품공학팀) ;
- 변명우 (한국원자력연구소 방사선식품공학팀)
- Published : 1998.08.01
Abstract
In order to investigate the radioprotective effect of Si-Wu-Tang (Korean name: Sa-Mul-Tang), a kind of traditional Oriental medicine as a blood-building decoction (Oriental medical concept: Bu-Xie), and Si-Jun-Zi-Tang (Korean name: Sa-Gun-Ja-Tang), one of the widely used Oriental herbal medicines as an energy tonic (Chinese medical concept: Bu-Qi). the jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were observed in irradiated mice. Jejunal crypts were protected by Si-Wu-Tang pretreated both per os (2 mg/mL of drinking water for 7 days, p<0.05) and intraperitoneally (1 mg/head, single injection at 24 hours before irradiation). Si-Wu-Tang adminstration before irradiation(1 mg/head, single injection at 24 hours before irradiation) resulted in an increase of the formation of endogenous spleen colony (p<0.005). The frequency of radiation-induced apoptosis in intestinal crypt cells was also reduced by pretreatment of Si-Wu-Tang (p<0.01). However, the radioprotective effect of Si-Jun-Zi-Tang was not as significant as that of Si-Wu-Tang. These results suggest that Si-Wu-Tang may be a useful radioprotective food, especially since it is a relatively nontoxic natural product.
한방 보혈제의 기본처방인 사물탕과 보기제의 기본 처방인 사군자탕의 방사선 조사 마우스에서의 방사선 방호 효과를 소장움 생존(고선량 방사선, 12 Gy), 조혈세포 생존(중간선량 방사선, 6.5 Gy), apoptosis 형성(저선량 방사선, 2 Gy) 실험법을 적용하여 관찰하였다. 방사선조사 전 사물탕투여군(경구투여: 음수 mL당 2 mg씩 7일간, 복강내주사: 마리당 1 mg씩 방사선 조사 24시간 전)에서 소장움의 생존이 증가되었으며 (방사선대조군: