Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Isolation and Quantitative Determination of Costunolide from Saussurea Root

목향(Saussureae Radix)으로부터 Costunolide의 분리 및 함량분석

  • Kim, Ju-Sun (Natural Products Research Institute, Seoul National University) ;
  • Chi, Hyung-Joon (Natural Products Research Institute, Seoul National University) ;
  • Chang, Seung-Yeup (Natural Medicines Standardization Division, Korea Food and Drug Administration) ;
  • Ha, Kwang-Won (Natural Medicines Standardization Division, Korea Food and Drug Administration) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
  • Published : 1999.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Isolation and quantitative determination of costunolide from Saussurea lappa Clarke (Compositae) has been conducted by using HPLC method. Costunolide in an acetone extract from the crude drug was separated on a RP-18 column using a $MeOH-H_20$ mixture (65:35) as an eluent and the average content is about $1.32{\sim1.42%.$ The content of costunolide in dried extract was decreased by about 24% in seven days. However it showed a slight decrease in solution. It is highly recommended that quantitative determination of costunolide from Saussureae Radix should be conducted as early as possible after solvent extraction.

Keywords