생약학회지 (Korean Journal of Pharmacognosy)

  • 제30권1호
  • /
  • Pages.48-53
  • /
  • 1999
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

목향(Saussureae Radix)으로부터 Costunolide의 분리 및 함량분석

Isolation and Quantitative Determination of Costunolide from Saussurea Root

  • Kim, Ju-Sun (Natural Products Research Institute, Seoul National University) ;
  • Chi, Hyung-Joon (Natural Products Research Institute, Seoul National University) ;
  • Chang, Seung-Yeup (Natural Medicines Standardization Division, Korea Food and Drug Administration) ;
  • Ha, Kwang-Won (Natural Medicines Standardization Division, Korea Food and Drug Administration) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
  • 발행 : 1999.03.30
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초록

Isolation and quantitative determination of costunolide from Saussurea lappa Clarke (Compositae) has been conducted by using HPLC method. Costunolide in an acetone extract from the crude drug was separated on a RP-18 column using a $MeOH-H_20$ mixture (65:35) as an eluent and the average content is about $1.32{\sim1.42%.$ The content of costunolide in dried extract was decreased by about 24% in seven days. However it showed a slight decrease in solution. It is highly recommended that quantitative determination of costunolide from Saussureae Radix should be conducted as early as possible after solvent extraction.

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