Archives of Pharmacal Research
- Volume 22 Issue 3
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- Pages.306-308
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Enzymatic Synthesis of a Dihydrobenzofuran Neolignan by Oxidative Coupling
- Yeo, Ho-Sup (ge of Pharmacy, Seoul National University) ;
- Lee, Jou-Heon (ge of Pharmacy, Seoul National University) ;
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Kim, Jin-Woong
(ge of Pharmacy, Seoul National University)
- Published : 1999.06.01
Abstract
The oxidative dimerization of ferulic acid has been carried out using horse-radish peroxidase as catalyst to give a dihydrobenzofuran neolignan (1), the structure of which was elucidated as (2SR, 3RS)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3n-butoxycarbonyl-5-(2E-carboxyethenyl)-7methoxybenzofuran by spectroscopic analyses. This compound showed more potent cytotoxicity against several tumor cell lines than the starting material.
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