Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
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Antimutagenicity of Phellinus linteus in Salmonella typhimurium

  • Shon, Yun-Hee (Department of Pharmacology, College of Medicine, Dongguk University, Kyungju) ;
  • Lee, Jae-Sung (Department of Food Science and Technology,) ;
  • Lee, Hang-Woo (Department of Biology, Yeungnam University, Kyongsan) ;
  • Kim, Joong-Wan (Department of Acupuncture and Moxibustion-Pointology) ;
  • Lim, Jong-Kook (Department of Acupuncture and Moxibustion-Pointology) ;
  • Kim, Cheorl-Ho (Department of Biochemistry, College of Oriental Medicine, Dongguk University, Kyungju) ;
  • Nam, Kyung-Soo (Department of Pharmacology, College of Medicine, Dongguk University, Kyungju)
  • Published : 1999.09.01
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Abstract

The mutagenicities and antimutagenicities of butanol (PL I) and water (PL II) extracts from the filtrate of the cultured broth of Phellinus linteus were examined using the Ames/Salmonella test. No mutagenic activity of PL I and PL II was found in Salmonella typhimurium strains TA98 and TA100, either with or without S9 activation. In contrast, PL I and PL II showed inhibitory effects on the mutagenic activities induced by the directly-acting mutagens, 4-nitro-o-phenylenediamine (NPD) using the tester strain TA98 and sodium azide (NaN3) using the tester strain TA 100 in the absence of S9 mix. PLI and PL II also showed inhibitory effects on the mutagenicities of the indirectly-acting mutagens, 2-aminofluorene (2-AF) using the tester strain TA98 and benzo[a]pyrene (B[a]P) using the tester strain TA 100 in the presence of S9. These results suggest that P. linteus has an antimutagenic activity and may play a role in the prevention of cancer.

Keywords

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