Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
권호 표지

An Antibacterial Compound against Pasteurella haemolytica Poduced by Streptomyces sp. 51086

반추동물 급성기관지폐렴균 Pasteurella haemolytica에 항균활성을 갖는 물질의 특성규명

  • 강희철 (생명공학연구소 세포기능제어 연구실) ;
  • 유인자 (생명공학연구소 세포기능제어 연구실) ;
  • 윤봉식 (생명공학연구소 세포기능제어 연구실) ;
  • 전용수 (국립수의과학검역원 세균과) ;
  • 유익동 (생명공학연구소 세포기능제어 연구실)
  • Published : 1999.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

Pasteurella haemolytica is well known to cause severe pneumonia, consolidation and oedema of the lung, and fibrinous pleurisy under the stress and infection of virus in the cattle. In the course of our screening for antimicrobial agents against P.haemloytica, compound 51086 has been isolated from the fermentation broth of Streptimyces sp. 51086. The compound 51086 was purified by SiO2, Sephadex LH-20 and ODS column chromatographies and HPLC, subsequently. The structure of compound 51086 was determined as hygromycin A by combination of 1H NMR, 13C NMR, HMBC, and ESI-MS. This compound showed significant antibacterial activity against P.haemolytica and P.multocida.

Keywords

References

  1. Infect. Immunol. v.58 Bovine pulmonary endothelial cell damage mediated by Pasteurella haemolytica pathogenic factors Breider, M. A.;S. Kumar;R. E. Corstvet
  2. J. Org. Chem. v.56 Total synthesis of antibiotic hygromycin A. Chida, N.;M. Ohtsuka;K. Nakazawa;S. Ogawa
  3. Can. J. Vet. Res. v.54 Molecular aspects of virulence of Pasteurella haemolytica Confer, A. W.;R. J. Panciera;K. D. Clinkenbeard;D. A. Mosier
  4. Am. J. Vet. Res. v.47 Effects of Pasteurella haemolytica lipopolysaccharide on selected functions of bovine lcukocytes Confer, A. W.;K. R. Simons.
  5. Res. Vet. Sci. v.37 Experimental production of bovine pneumonic pasteurellosis Gibbs, H. A.;E. M. Allan;A. Wiseman;I. E. Selman
  6. J. Antibiotics v.50 Structure-activity relationships of hygromycin A and its analogs: protein synthesis inhibition activity in a cell free system Hayashi, S. F.;L. J. L. Norcia;S. B. Seibel;A. M. Silvia
  7. J. Antibiotics v.45 Semisynthetic hygromycin A analogs: synthesis and antibacterial activity of derivatives lacking the furanose moiety Jaynes, B. H.;N. C. Elliott;D. L. Schicho
  8. J. Agr. Sci. Vet. v.35 Pathological studies on the calf pneumonia experimentally induced by endotoxin and leukotoxin of Pasteurella haemolytica A1 Jean, Y. H.;U. B. Bak
  9. J. Agr. Sci. Vet. v.35 Pathological studies on the calf pneumonia experimentally induced by Pasteurella haemolytica A1 Jean, Y. H.;U. B. Bak
  10. Agric. Biol. Chem. v.42 Nuclear magnetic resonance and structure of hygromycin Kakinuma, K.;Y. Sakagami
  11. J. Bacteriol. v.174 Separable domains define target cell specificities of an RTX hemolysin from Actinobacillus pleuropneumoniae McWhinney, D. R.;Y. F. Chang;R. Young;D. K. Struck
  12. J. Antibiotics v.40 Hygromycin A, an antitreponemal substance Nakagawa, A.;T. Fujimoto;S. Omura
  13. J. Antibiotics v.52 Studies on time-kill kinetics of different classes of antibiotics aginst veterinary pathogenic bacteria including Pasterella, Actinobacillus and Escherichia coli Norcia, L. J. L.;A. M. Silvia;S. F. Hayashi
  14. J. Antibiotics v.40 Hygromycin A, an antitreponemal substance Omura, S.;A. Nakagawa;T. Fujimoto;K. Saito;K. Otofuro;J. C. Walsh
  15. Anti. Chem. v.3 Hygromycin I. Preliminary studies on the production and biologyc activity of a new antibiotic Pittenger, R. C.;R. N. Wolfe;M. M. Hoehn;P. N. Marks;W. A. Daliy;J. M. McGuire
  16. J. Gen. Microbiol. Ave. Soc. Gen. Microbiol. v.136 Time and ternperature dependence of granulocyte damage by leucotoxic supernatant from Pasteurella haemolytica A1 Styrt, R.;R. D. Dahl;L. D. Potter
  17. Am. J. Vet. Res. v.46 Experimental reproduction of septicemic pasteurellosis in feedlot lambs : Bacteriologic and pathologic examinations Suarez-Guames, F.;M. T. Collins;C. E. Whiteman