Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지

The Radioprotective Effect of Kuei-Pi-Tang as a prescription of Traditional Chinese Medicine in Mice

생쥐에서 귀비탕 및 구성단미의 방사선 방호효과

  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Song-Eun (College of Veterinary Medicine, Chonnam National University) ;
  • Oh, Heon (College of Veterinary Medicine, Chonnam National University) ;
  • Yang, Jung-Ah (College of Veterinary Medicine, Chonnam National University) ;
  • Chung, Chi-Young (College of Veterinary Medicine, Chonnam National University) ;
  • Jang, Jong-Sik (Department of Animal Science, Sangju National University) ;
  • Yu, Young-Beob (Food Irradiation Team, Korea Atomic Energy Research Institute) ;
  • Jo, Sung-Kee (Food Irradiation Team, Korea Atomic Energy Research Institute)
  • 김성호 (전남대학교 수의과대학) ;
  • 이송은 (전남대학교 수의과대학) ;
  • 오헌 (전남대학교 수의과대학) ;
  • 양정아 (전남대학교 수의과대학) ;
  • 정치영 (전남대학교 수의과대학) ;
  • 장종식 (상주대학교 축산학과) ;
  • 유영법 (한국원자력연구소 방사선식품〮생명공학기술개발) ;
  • 조성기 (한국원자력연구소 방사선식품〮생명공학기술개발)
  • Published : 1999.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

In this study, we evaluated the radioprotective effects of Kuei Pi Tang and its ingredients, as a prescription of traditional Oriental medicine. The jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in mice irradiated with high and low dose of ${\gamma}$ rays. In the mice administered with Kuei Pi Tang extract before irradiation, the jejunal crypts were protected significantly(p<0.005) and the frequency of radiation induced apoptosis was reduced(p<0.05). In the experiment on the effects of the ingredients of Kuei Pi Tang, the results indicated that the extract of Dangui(Angelica sinensis), Suanzaoren(Zizyphus valgaris), Rensan (Panax ginseng), Fuling(Poria cocos) and Muxiang(Saussurea lappa) might have a major radioprotective effect. Although the mechanisms of this inhibitory effect remain to be elucidated, these results indi cated that Kuei Pi Tang might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

Keywords

References

  1. Manual on Early Medical Treatment of Possible Radiation Injury IAEA safty No. 47 IAEA
  2. Management of Persons Accidentaly Contaminated with Radionuclides NCP report No. 65 NCP
  3. Science v.110 Cystein protects aginst X-irradiation Patt, H.;Tyree, M.;Straube, R. L.
  4. Cancer Res. v.42 Pretective effects of S-2-(3-aminopropylamino) ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice Milas, L.;Hunter, N.;Reid, B. O.;Thames, Jr. H. D.
  5. Pharmacol. Ther. v.39 Radioprotectors in tumor radiotherapy: Factors and settings determining therapeutic ratio Milas, L.;Murray, D.;Brock, W. A.;Meyn, R. E.
  6. J. Immunol. v.136 Interleukinl is a radioprotector Neta, R.;Douches, S.;Oppenheim, J. J.
  7. Pharmacol. Ther. v.39 Role of cytokines in radioprotection Neta, R.
  8. Int. J. Radiat. Biol. v.57723-736 Therapeutic use of recombinant human G-CSF(rhG-CSF) in a conine model of sublethal and lethal whole body irradiation MacVittie, T. J.;Monroy, R. L.;Patchen, M. L.;Souza, L. M.
  9. A survey of compounds from the antiradiation drug development program of the U. S. army medical research & development command Sweeny, T. R.
  10. Cancer Clin. Trials v.3 Phase I clinical studies with WR2721 Iligerman, M. M.;Shaw, M. T.;Slavid, M.;Yudas, J. M.
  11. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.12 Immunological and hematopoietic effect of Codonopsis pilosula on cancer patients during radiotherapy Zneg, X. L.;Li, Z. A.;Zhang, B. Y.
  12. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.12 Clinical and experimental study on shen-qiinjection with chemotherapy inthe treatment of malignant tumor of digestive tract Li, N. Q.
  13. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.17 Studies of Rehmannia glutinosa Libosch. F. hueichingensis as a bleed tonic Yuan, Y.;Hou, S.;Lian, T.;Han, Y.
  14. Chin. Med. J. Engl. v.104 Advances in the pharmacological studies of radix Angelica sinensis(Oliv) Diels(Chinese Danggui) Mei, Q. B.;Tao, T. Y.;Cui, B.
  15. Exp. Hematol. v.16 Radioprotection of hemopoiesis conferred by Acanthopanax senticosus Harms(Shigoka) administered befere or after irradiation Miyanomae, T.;Frindel, E.
  16. Chung-Hua-I-Hsueh-Hsueh-Pao v.76 The effect of angelica polysaccharide on proliferation and differentiation of hematopoietic progenitor cell Wang, Y.;Zhu, B.
  17. Yao-Hsueh-Hsueh-Pao v.28 Effects of Phytolacca acinosa polysaccharides Ⅱon lymphocyte proliferation and colony stimulating factor production from mice splenocytes in vitro Wang, H. B.;Zheng, Q. Y.;Ju, D. W.;Fang, J.
  18. Yakugaku Zasshi v.110 Studies on chemical protectors against radiation. ⅩⅩⅩ. Radioprotective substances of cnidii rhizoma Ohta, S.;Sakurai, N.;Sato, Y.;Inoue, T.;Shinoda, M.
  19. Am. J. Clin. Med. v.18 Radioprotective effect of Ganoderma lucidum(Leyss. ex. Fr.) Karst after X-ray irradiationin mice Hsu, H. U.;Lian, S. L.;Lin, C. C.
  20. Chung-Kuo-Chung-Yao-Tsa-Chih v.19 Effects of radix Astragali on hemopoiesis in irradiated mice Quan, H. X.;Li, H. S.
  21. Int. J. Cancer v.62 Interleukin-11 protects the clogenic stem cell in murine small-intestinal crypts from impairment of their reproductive capacity by radiation Potten, C. S.
  22. J. Histochem. Cytochem. v.41 A new method to detect paoptosis in paraffin section: In sity end-labeling of fragmented DNA Wijsman, J. H.;Jonker, R. R.;Keijzer, R.;Van Velde, C. J. H.;Corneliess, C. J.;Van Dierendonck, J. H.
  23. Radiat. Res. v.59 Distribution of WR-2721 in normal and malignant tissue of mice and rats bearing solid tumors: Dependence on tumor type, druh dose and species Washbrun, L. C.;Carlton, J. E.;Hayes, R. L.
  24. Radiat. Res. v.94 Adverse effect of radioprotector WR2721 Cairnie, A. B.
  25. J. Ethnopharmacol. v.52 Protection of mouse bone marrow by Si-Wu-Tang against whole body irradiation Hsu, H. Y.;Ho, Y. H.;Lin, C. C.
  26. Int. J. Immunopharmacol. v.16 Recipient-mediated effect of a traditional Chinese herbal medicine, ren-shen-yang-rong-tang(Japanese name: niunjin-youei-to), on hematopoietic recoveryfollowing lethal irradiation and syngeneic bone marrow transplantation Fujii, Y.;Imamura, M.;Han, M.;Hashino, S.;Zhu, X.;Kobayashi, H.;Imai, K.;Kasai, M.;Sakurada, K.;Miyazaki, T.
  27. Yakugaku Zasshi v.110 Protective activities of a Chinese medicine, hochuekki-to, to impairment of hematopoietic organs and to microbial infection Ikeda, S.;Kaneko, M.;Kumazawa, Y.;Nishimura, C.
  28. Exp. Hematol. v.18 Effects of juzen-taiho-toh(TJ-48), A traditional Oriental medicine, on hematopoietic recovery from radiation injury in mice Ohnishi, Y.;Yasumizu, R.;Fan, H. X.;Liu, J.;Takao-Liu, F.;Komatsu, Y.;Hosoya, E.;Good, R. A.;Ikehara, S.
  29. J. Ethmopharmacol. v.54 Recovery of the hematopoietic system by Si-Jun-Zi-Tang in whole body irradiated mice Hsu, H. Y.;Yang, J. J.;Lian, S. L.;Ho, Y. H.;Lin, C. C.
  30. Am. J. Chin. Med. v.24 Si-jun-zi-tnag regulated granulocyte macrophage colony-stimulating factor secretion by human peripheral blood mononuclear cells Tseng, J.;Li, T. L.
  31. Am. J. Chin. Med. v.21 Efects of Kuei-Pi-Tang on cellular immunocompetence of gamma-irradiated mice Hsu, H. Y.;Hau, D. M.;LIn, C. C.
  32. Chung-Kuo-Chung-Yao-Tsa-Chih v.16 Theabsorption of Fe, Zn, Cu in siwu, sijunzi, and Liuwei dihuang decoction by small intestine in rats Lu, G. Yang, M.;Shen, Y.;Meng, J.
  33. In Vivo v.7 In vivo radioprotective activity of Panax ginseng and diethyldithiocarbamate Kim, S. H.;Cho, C. K.;Yoo, S. Y.;Koh, K. H.;Yun, H. G.;KIm, T. H.
  34. J. Med. Pharm. Soc. WakanYaku v.3 Radioprotective effect of Chinese medicinal prescriptions in mice Hosokawa, Y.
  35. Am. J. Chin. Med. v.21 Preliminary study on the anti-radiation effect of Jen-Sheng-Yang-Yung-Tang Hsu, H. Y.;Ho, Y. H.;Lian, S. L.;Lin, C. C.
  36. Am. J. Chin. Med. v.19 Preliminary study on antiradiation effect of Kuei-Pi-Tang Hsu, H. Y.;Ho, Y. H.;Lian, S. I.;Lin, C. C.
  37. 한약조제 지침서 해설 한약위원회;조제지침연구소위원회
  38. 한약방제학 약대 한약학 교재연구회
  39. 최신 고려 인삼(성분 및 효능 편) 남기열
  40. J. Radiat. Res. v.17 Restoration of radiation injury by intraperitoneal injection of ginseng extract in mice Yonezawa, M.
  41. J. Radiat. Res. v.22 Restoration of radiation injury by ginseng Ⅱ. Some properties of the radioprotective substances Yonezawa, M.;Katoh, N.;Takeda, A.;
  42. J. Radiat. Res. v.22 Restoration of radiation injury by sinseng. Ⅰ. Responses of X-irradiated mice to ginseng extract Takeda, A.;Yonezawa, M.;Katoh, N.
  43. J. Radiat. Res. v.26 Restoration of radiation injury by ginseng.Ⅳ.Stimulation of recoveries in CFUs and megakaryocyte counts related to the prevention of occult blood appearnce in X-irradiated mice Yonezawa, M.;Katoh, N.;Takeda, A.
  44. J. Radiat. Res. v.23 Restoration of radiation injury by ginseng.Ⅲ.Radioprotective effect of thermostable fraction of ginseng extract on mice, rats and guinea pigs Takeda, A.;Katoh, N.;Yonezawa, M.
  45. J. Radiat. Res. v.112 Modification of radiation response in mice by fractionated extracts of Panax ginseng Zhang, J. S.;Sigdestad, C. P.;Gemmell, M. A.;Grdina, D. J.
  46. In Vivo v.12 Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice Kim, S. H.;Jeong, K. S.;Ryu, S. Y.;Kim, T. H.
  47. Chin. Med. J. v.104 Advances in the pharmacological studies of radix Angelica sinsesis(oliv)diels(Chinese Danggui) Mei, Q. B.;Tao, J. Y.;Cui, B.
  48. Am. J. Chin. Med. v.24 Si-Jun-Zi-Tang regulate granulocyte marcrophage colony-stimulating factor secretion by human peripheral blood monouclear cells Tseng, J.;Li, T. L.
  49. Chung-Kuo-Chung-Hsi-I-Chieh-Ho-Tsa-Chih v.16 Clinical and experimental study on treatment of rotavirus enteritis with qiwei baizhu powder He, S. T.;He, F. Z.;Wu, C. R.
  50. Yakugaku Zasshi v.111 Imaging analysis of antiulcer action and the active constituent of Atractyloides rhizoma Matsuda, H.;Li, Y. H.;Tanguchi, K.;Yamahara, J.;Tamai, Y.
  51. Yakugaku Zasshi v.111 The effect of crude drugs using diuretic on horse kidney(Na+＋K+)-adenosine triphosphatase Satoh, K.;Yasuda, I.;Nagai, F.;Ushiyama, K.;Akiyama, K.;Kano, I.
  52. Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol. v.113 Effect of traditional herbal medicine on gastric mucin against ethnol-induced gastric injruy in rats Goso, Y.;Ogata, Y.;Ishhara, K.;Hotta, K.
  53. J. Pharmacobiodyn. v.7 Comparative studies of the steroisomers of glycyrrhetinic acid on anti-inflammatory activities Amagaya, S.;Sugishita, E.;Ohihara, Y.;Ogawa, K.;Aizawa, T.
  54. Chung-Kuo-Chung-Yao-Tsa-Chih v.15 A preliminary study on the pharmacology of the compound prescription huanggin tang and its component drugs Huang, L.;Ye, B.;Cai, B.;Li, D.;Liu, J.;Liu, M.
  55. Am. J. Chin. Med. v.9 Screening of the wormicidal Chinese raw dugs on Clonorchis sinensis Rhee, J. K.;Woo, K. J.;Baek, B. K.;Ahn, B. J.
  56. Chem. Pharm. Bull. v.41 Saussureamines A, B, C, D and E, new anti-ulcer principles from Chinese saussureae radix Yoshikawa, M.;Hatakeyama, S.;Inoue, Y.;Yamahara, J.
  57. Chem. Pharm. Bull. v.45 Bioactive saponins and glycisides. X. on the constituents of zizyphi spinosi semen, the seeds of zizyphus jujuba mill. var. spionsa Hu(1): structure and histamine release-inhibitory effect of jujubosides A1 and C and acetyljujuboside B. Yoshikawa, M.;Murakami, T.;Ikebata, A.;Wakao, S.;murakami, N.;Matsuda, H.;Yamahara, J.