Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지

Growth Suppression Effect of Traditional Fermented Soybean Paste(Doenjang) on the Various Tumor Cells

순창 재래식 된장의 암세포 성장억제 효과

  • Published : 1999.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

Methanol extract and its fraction of traditional fermented soybean paste(doenjang) from Soonchang area were studied for growth suppression on the various tumor cells and suppression components, by using HPLC and GC were analysed. Hexane fraction of methanol extract was indicated 79%, 76%, 67%, 66%, 78% of growth suppression on L1210, P338D1, HepG2, WiDr and SNU 1 tumor cells, respectively. Ethylacetate fraction of methanol extract also showed 81%, 75%, 75%, 76% and 82% of growth suppression on the same tumor cells, respectively. Peak 8 obtained from HPLC of ethylacetate fraction indicated 81%, 77%, 77%, 75% and 79% of growth suppression on the same tumor cells and identified as a genistein, by comparing with standard one by HPLC analysis. Hexane fraction of methanol extract contained oleic acid, linoleic acid and palmitic acid.

Keywords

References

  1. 한국식품과학회 국제심포지움 초록 콩과 현대인의 건강, 현대인의 건강을 위한 콩단백질의 영양과 이용 권태완
  2. Cancer Res. v.41 Effects of protease inhibitors on radiation transformation in vitro Kennedy, A. R.;Little, J. B.
  3. Cancer Res. v.43 Bowman-Birk soybean protease inhibitor as an anticarcinogen Yavelow, J.;Finlay, T. H.;Kennedy, A. R.;Troll, W.
  4. Cancer Res. v.50 Supression of dimethylhydrazine-induced carcinogenesis in mice by dietary addition of the Bowman-Birk protease inhibitor St. Clair, W. H.;Billings, P. C.;Carew, J. A.;McGandy, C. K.;Newberne, P.;Kennedy, A. R.
  5. Carcinogenesis v.10 Inositol and inositol hexaphosphate supress cell proliferation and tumor formation in CD-1 mice Shamsuddin, A. M.;Ullah, A.;Chakravarthy, A. K.
  6. Carcinogenesis v.9 Supression of large intestinal cancer in F344 rats by inositol hexaphosphate Shamsuddin, A. M.;Elsayed, A. M.;Ullah, A.
  7. J. Agric. Food Chem. v.41 Genistein, daidzein, and their β-glycoside conjugates:antitumor isoflavones in soybean foods from american and Asian diets Coward, L.;Barnes, N. C.;Stechell, K. D. R.;Barnes, S.
  8. Biochim. Biophys. Res. Commun. v.179 Genistein inhibition of the human breast cancer cells: Independence from estrogen receptors and the multi-drug registance gene Peterson, G.;Barnes, S.
  9. Food Chem. Toxic. v.26 Reduction of benzo(a)pyren-induced mouse forestomach neoplasms in mice given nitrite and dietary soy sauce Benjamin, H.;Storkson, J.;Tallas, P. G.;Pariza, M. W.
  10. Cancer Res. v.51 Inhibition of benzo(a)pyren-induced mouse forestomach neoplasia by dietary soy sauce Benjamin, H.;Storkson, J.;Nagahara, A.;Pariza, M. W.
  11. Cancer Res. v.52 Inhibition of benzo(a)pyren-induced mouse forestomach neoplasia by a principal flavor component of japanese-style germented soy sauce Nagahara, A.;Benjamin, H.;Storkson, J.;Krewson, J.;Sheng, K.;Liu, W.;Pariza, M. W.
  12. J. Sci. Food Agric. v.58 Antimutagenicity and mutagen-binding activation of mutagenic purolyzates by microorganisms isolated from Japanese miso Asahara, N.;Zhang, X. B.;Ohta, Y.
  13. J. Kor. Soc. Food Nutr. v.22 Antioxidative activity of browning products fractionated from fermented soybean sauce Cheigh, H. S.;Lee, J. S.;Moon, G. S.;Park, K. Y.
  14. J. Kor. Soc. Food Nutr. v.22 Antioxidative activity of browning products fractionated from fermented soybean sauce Cheigh, H. S.;Lee, J. S.;Moon, G. S.;Park, K. Y.;
  15. J. Kor. Soc. Food Nutr. v.22 Antioxidative characteristics of melanoidin related products fractionalted from fermented soybean sauce Cheigh, H. S.;Lee, J. S.;Lee, C. Y.
  16. J. Kor. Soc. Food Nutr. v.19 Antimutagenic effect of doenjang(Korean fermented soy paste) toward aflatoxin Park, K. Y.;Moon, S. H.;Baik, H. S.;Cheigh, H. S.
  17. 마우스에서 된장 추출물의 항암 효과 및 기작 연구: 부산대학교 대학원 석사학위논문 손미현
  18. 된장의 항돌연변이 및 항암효과. 부산대학교 대학원 박사학위논문 임선영
  19. Korean J. Appl. Microbiol. Bioengnol. v.25 Cytotoxicity testing of fermented soybean products with various tumor cells using MTT assay Chung, K. S.;Yoon, K. D.;Kwon, D. J.;Hong, S. S.;Choi, S. Y.
  20. Cancer Res. v.48 Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazelium assay Alley, M. C.;Scudiero, D. A.;Monks, A.;Hursey, M. L.;Czerwinski, M. J.;Fine, D. L.;Abbott, B. J.;Mayo, J. G.;Shoemaker, R. H.;Boyd, M. R.
  21. Kor. J. Nutr. v.23 A study on the cytotoxic activity of garlic(Allium sativum) extract against cancer cells Son, H. S.;Hwang, W. I.
  22. Phytochemistry v.12 A new isoflavone from soya beans Naim, M.;Gestetner, B.;Kirson, I.;Brik, Y.;Bondi, a.
  23. Anlaytical Sci. v.2 Analysis of non-volatile organic acids with capillary gas chromatography Ha, J. H.;Hawer, W. D.;Park, Y. K.;Nam, Y. J.
  24. Cancer Res. v.41 Epidemiologic cerrelation between diet and cancer frequency Correa, P.
  25. Cancer Res. v.35 Role o life-style and dietary habits in risk of cancer among Seventh Day Adventisits Phillips, R. L.
  26. Chemically induced cell proliferation : Implications for risk assesment Inhibitory effects of soybean trypsin ingibitor during initiation and promotion phases of N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis Takahashi, M.;Imaida, K.;Furukawa, F.;Hayashi, Y.
  27. J. Natl. Cancer Inst. v.76 Inhibitions of oral carcinogenesis by a protease inhibitor Messadi, D. V.;Billings, P. C.;Shaklar, G.;Kennedy, A. R.
  28. Carcinogenesis v.11 Protease inhibitor suppression of colon and gland cacinogenesis induced by dimethyldrazine Billings, P. C.;Newberne, P. M.;Kennedy, A. R.
  29. Carcinogenesis v.12 Inhibition of spontaneous hepatocarcinogenesis in C3H/10T1/2 mice by Edi Pro A, an isolated soy protein Becker, F. F.
  30. diet and cancer : Marders, prevention and treatment Potetial role of dietary isoflavones in the prevention of cancer Barnes, S.;Peterson, G.;Grubbs, C.;Setchell, K. D. R.;Jacobs, M. M.(ed.)
  31. J. Biol. Chem. v.262 Genistein, specific inhibitor of tyrosine specific protein kinase Akiyama, T.;Ishida, J.;Nadagawa, S.;Ogawa, H.;Watanabe, S.;Ito, N.;Shibuya, M.;Fukami, Y.
  32. Oncogene v.6 Inhibition of PDGF-induced c-jun and c-fos expression by a tyrosine protein kinase inhibitor Zwiller, J.;Sassone-Crosi, P.;Kakazu, K.;Boynton, A. L.
  33. J. Natl. Cancer Inst. v.78 Cytotoxic effects of free fatty acids on ascites tumor cells Siegel, I.;Liu, T. L.;Yaghoubzadeh, E.;Keskey, T. S.;Gleicher, N.