Archives of Pharmacal Research
- Volume 23 Issue 3
- /
- Pages.240-242
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- 2000
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Immunomodulating Activity of a Polysaccharide Isolated from Mori Cortex Radicis
- Kim, Hwan-Mook (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
- Han, Sang-Bae (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
-
Lee, Ki-Hoon
(Korea Research Institute of Bioscience and Biotechnology(KRIBB))
;
-
Lee, Chang-Woo
(Korea Research Institute of Bioscience and Biotechnology(KRIBB))
;
- Kim, Chul-Young (College of Pharmacy, Seoul National University) ;
-
Lee, Eun-Ju
(College of Pharmacy, Seoul National University)
;
-
Huh, Hoon
(ollege of Pharmacy, Seoul National University)
- Published : 2000.06.01
Abstract
The immunomodulating activity of a polysaccharide isolated from Morus alba (PMA) root bark was examined in murine splenic lymphocytes. PMA enhanced proliferation of splenic lymphocytes in a synergistic manner in the presence of mitogens. However, PMA suppressed pri-may IgM antibody production from B cells, which was activated with lipopolysaccharide, a polyclonal activator, or immunized with a T-cell dependent antigen sheep red blood cells. Our observations showed that the immunomodulating activity of PMA increased lymphocyte proliferation and that PMA decreased antibody production from B cells, which was distinct from those of other plant-originated polysaccharides.
Keywords