Archives of Pharmacal Research
- Volume 23 Issue 4
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- Pages.302-309
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of (-)-Neplanocin A Analogues as Potential Antiviral Agents
- Shin, Dae-Hong (College of Pharmacy, Seoul National University) ;
- Lee, Hyuk-Woo (College of Pharmacy, Seoul National University) ;
- Park, Sung-Soo (College of Pharmacy, Seoul National University) ;
- Kim, Joong-Hyup (Korea Institute of Science and Technology) ;
- Jeong, Lak-Shin (College of Pharmacy, Ewha Womans University) ;
- Chun, Moon-Woo (College of Pharmacy, Seoul National University)
- Published : 2000.08.01
Abstract
Based on (-)-neplanocin A with the 5'-hydroxyl substituted with fluoro, azido, or amino group, the corresponding xylo- and arabino derivatives were synthesized from D-ribose using the Mit-sunobu reaction as a key step. None of the final nucleosides did show either significant antiviral activities or cytotoxicities.
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