Archives of Pharmacal Research
- Volume 23 Issue 4
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- Pages.310-314
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Antimicrobial Activity of some New 2-Indolinone Derived Oximes and Spiro-Isoxazolines
- El Gendy, Adel A. (Department of Organic Chemistry and Microbiology, Faculty of Pharmacy, Cairo University) ;
- Ahmedy, Aly M. (Department of Organic Chemistry and Microbiology, Faculty of Pharmacy, Cairo University)
- Published : 2000.08.01
Abstract
The synthesis and spectral analysis of some new 1,3-dihydro-3-hydroxy-3-[2-hydroxyimino-2-(substituted phenyl)ethyll-2H-indol-2-ones (21-32) and spiro[3H-indol-3,5'-(4'H)-isoxazol]-2(1 H)-ones (33-44) are described. Sixteen of the synthesized compounds were screened in vitro for their growth inhibitory activity against thirteen species of microorganisms, viz, S. aureus, S. epidermidis, S. faecalis, B. subtilis, B. cereus, E. aerogens, E. coli, P. aeruginosa, P. vulgaris, A. baumonia, A. faecalis, C. albicans and S. cervicae. Most of the compounds exhibited significant antimicrobial activity especially the oximes 28 and 29.