Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Idiopathic CD4+ T-Lymphocytopenia with Disseminated Mycobacterium kansasii Infection and Pulmonary Alveolar Proteinosis

미만성 Mycobacterium kansasii 감염과 폐포단백증을 동반한 특발성 CD4+ 림프구감소증 1예

  • Park, So-Yeon (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center) ;
  • Park, Jae-Hyung (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center) ;
  • JeGal, Yang-Jin (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center) ;
  • Lee, Ji-Hyun (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center) ;
  • Lim, Chae-Man (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center) ;
  • Lee, Sang-Do (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center) ;
  • Koh, Youn-Suck (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center) ;
  • Kim, Woo-Sung (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center) ;
  • Kim, Dong-Soon (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center) ;
  • Kim, Won-Dong (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center) ;
  • Shim, Tae-Sun (Department of Internal Medicine, University of Ulsan College of Medicine Asan Medical Center)
  • 박소연 (울산대학교 의과대학 서울중앙병원 내과학교실) ;
  • 박재형 (울산대학교 의과대학 서울중앙병원 내과학교실) ;
  • 제갈양진 (울산대학교 의과대학 서울중앙병원 내과학교실) ;
  • 이지현 (울산대학교 의과대학 서울중앙병원 내과학교실) ;
  • 임채만 (울산대학교 의과대학 서울중앙병원 내과학교실) ;
  • 이상도 (울산대학교 의과대학 서울중앙병원 내과학교실) ;
  • 고윤석 (울산대학교 의과대학 서울중앙병원 내과학교실) ;
  • 김우성 (울산대학교 의과대학 서울중앙병원 내과학교실) ;
  • 김동순 (울산대학교 의과대학 서울중앙병원 내과학교실) ;
  • 김원동 (울산대학교 의과대학 서울중앙병원 내과학교실) ;
  • 심태선 (울산대학교 의과대학 서울중앙병원 내과학교실)
  • Published : 2000.03.30
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Abstract

Idiopathic CD4+ T-lymphocytopenia is defined as a depletion of CD4+ lymphocytes below $300/mm^3$ in the absence of HIV infection or other known causes of immunodeficiency. Many infectious diseases have been reported to be associated with idiopathic CD4+ T-lymphocytopenia, and there have also been a few cases of mycobacterial infection in idiopathic CD4+ T-lymphocytopenia. Until now, it has been unclear as to whether CD4+ T-lymphocytopenia is a predisposing factor for or a consequence of the mycobacterial infection. Pulmonary alveolar proteinosis is an uncommon disease characterized by the intraalveolar deposition of amorphous granular material that stains positive with PAS, and its association with mycobacterial infection has rarely been reported. Recently, we experienced a previously healthy young man who had been diagnosed as idiopathic CD4+ T-lymphocytopenia with disseminated mycobacterium kansasii infection and pulmonary alveolar proteinosis, and report this case.

본 저자들은 평소 건강하였던 31세 남자 환자가 원인불명열로 발현하여 미만성 Mycobacterium kansasii 감염과 폐포단백증으로 진단받고, 동반된 특발성 CD4+ 렴프구감소종이 기저 면역장애의 원인으로 밝혀진 예를 경험하였기에 보고하는 바이다.

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