Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Studies on the anti-inflammatory action of Chilbokyeum extract in central nervous system

중추신경계(中樞神經系)에서 칠복음(七福飮)의 항염증작용(抗炎症作用)에 관한 연구(硏究)

  • Min Sang-Jun (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee Sung-Ryull (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kang Hyung-Won (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lyu Yeoung-Su (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Jeon Chang-Hwan (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University)
  • 민상준 (원광대학교 한의과대학 한방신경정신과학 교실) ;
  • 이성률 (원광대학교 한의과대학 한방신경정신과학 교실) ;
  • 강형원 (원광대학교 한의과대학 한방신경정신과학 교실) ;
  • 류영수 (원광대학교 한의과대학 한방신경정신과학 교실) ;
  • 전창환 (원광대학교 한의과대학 한방신경정신과학 교실)
  • Published : 2001.12.30
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Abstract

Substance P can stimulate secretion of tumor necrosis $factor-\;{\alpha}\;(TNF-\;{\alpha}\;)$ from astrocytes stimulated with lipopolysaccharide (LPS). Here I report that Chilbogeum can modulate cytokines secretion from primary cultures of rat astrocytes. Chilbogeum $(10\;{\mu}g/ml)$ significantly inhibited the $TNF-\;{\alpha}$ secretion by astrocytes stimulated with LPS and Substance P. Interleukin-1 (IL-1) has been shown to elevate $TNF-\;{\alpha}$ secretion from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. Treatment of Chilbogeum $(10,\;100\;{\mu}g/ml)$ to astrocytes stimulated with both LPS and Substance P decreased IL-1 secretion significantly. The secretion of $TNF-\;{\alpha}$ by LPS and Substance P in astrocytes was progressively inhibited with increasing amount of IL-1 neutralizing antibody. Upon stimulation from various agents, these cells adopt a reactive phenotype, a morphological hallmark in Alzheimer's disease (AD) pathology, during which they themselves may produce still more inflammatory cytokines. Chilbogeum $(10,\;100\;{\mu}g/ml)$ significantly inhibited the $TNF-\;{\alpha}$ secretion by CCF-STTG1 astrocytoma cells stimulated with $A\;{\beta}$ and IL-1. These results suggest that Chilbogeum may inhibit $TNF-\;{\alpha}$ secretion by inhibiting IL-1 secretion and that Chilbogeum has an antiinflammatory activity in AD brain.

Keywords

References

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