Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Effects of acupuncture on nNOS-positive neurons in cerebrocortex of streptozotocin-induced diabetic rats

Streptozotocin으로 유발된 당뇨병 흰쥐 대뇌피질에서 침이 Neuronal Nitric Oxide Synthase 발현에 미치는 영향

  • Kim, Ee-Hwa (Departments of Acupuncture & Moxibustion and Meridianology, College of Oriental Medicine, Se-Myung University) ;
  • Hwang, Dae-Yeon (Departments of Acupuncture & Moxibustion and Meridianology, College of Oriental Medicine, Se-Myung University) ;
  • Lee, Eun-Yong (Departments of Acupuncture & Moxibustion and Meridianology, College of Oriental Medicine, Se-Myung University) ;
  • Jang, Mi-Hyun (Departments of Physiology, College of Medicine, Kyung-Hee University) ;
  • Kim, Youn-Jung (Departments of Physiology, College of Medicine, Kyung-Hee University) ;
  • Chung, Joo-Ho (Department of Pharmacology, College of Medicine, Kyung-Hee University) ;
  • Seo, Jung-Chul (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dong-Eui University) ;
  • Kim, Chang-Ju (Departments of Physiology, College of Medicine, Kyung-Hee University)
  • 김이화 (세명대학교 한의과대학 침구.경혈학교실) ;
  • 황대연 (세명대학교 한의과대학 침구.경혈학교실) ;
  • 이은용 (세명대학교 한의과대학 침구.경혈학교실) ;
  • 장미현 (경희대학교 의과대학 생리학교실) ;
  • 김연정 (경희대학교 의과대학 생리학교실) ;
  • 정주호 (경희대학교 의과대학 약리학교실) ;
  • 서정철 (동의대학교 한의과대학 침구학교실) ;
  • 김창주 (경희대학교 의과대학 생리학교실)
  • Received : 2001.08.18
  • Accepted : 2001.08.25
  • Published : 2001.10.20
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Abstract

It has known that acupuncture exerts various effects, such as analgesia, promotion of homeostasis, improvements in brain circulation, and rectification of internal disorders in Oriental medicine. Of particular, acupuncture at the Zusanli acupoint (ST36) has been widely used to relieve symptoms of diabetes mellitus. The effect of acupuncture at Zusanli on neuronal nitric oxide synthase (nNOS)-positive neurons in streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry. Decreased nNOS-positive neurons was detected in cerebrocortex of STZ-induced diabetic rats. Needling on the Zusanli in diabetic rats resulted in increase of nNOS-positive neurons in cerebrocortex, The present study indicate that acupuncture may affect nNOS-positive neurons in cerebrocortex of STZ-induced diabetic rats.

Keywords

References

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