Journal of Food Hygiene and Safety (한국식품위생안전성학회지)
- Volume 16 Issue 4
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- Pages.349-354
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- 2001
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- 1229-1153(pISSN)
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- 2465-9223(eISSN)
Antioxidant Effects of Sesamin and Sesamolin in Streptozotocin-induced Diabetes Mellitus Rat
Streptozotocin유발 당뇨쥐에서 세사민과 세사몰린의 항산화효과
Abstract
Oxidative stress is believed to play an important role in the development of vascular complications associated with diabetes mellitus. We examined the antioxidative effect of sesamin and sesamolin on the preventing the development of insulin dependent diabetes mellitus using streptozotocin-induced Spraque Dawley diabetic rats. From 48 hours after injection of streptozotocin (60 mg/kg body weight), a portion of diabetic rats were fed with 0.2% sesamin and sesamolin containing diet for 3 weeks. There were significant differences of blood glucose and kidney weight between diabetic ports and control. Sesamin and sesamolin increased glutathione-S-transferase activity in kidney. The concentration of the thiobarbituric acid-reactive substances in the serum, liver, and kidney of diabetic rats administered sesamin and sesamolin decreased significantly as compared with that of the non-treated diabetic group. Dietary sesamin and sesamolin suppressed the oxidative stress in the diabetic rats. These results demonstrated that sesamin and sesamolin are potential and effective antioxidants that can protect the complications associated with diabetes.
산화적 스트레스는 당뇨병과 관련된 맥관계병변의 전개에 아주 중요한 역할을 한다고 알려져 있다. 따라서 본 실험에서는 streptozotocin(STZ)투여에 의한 당뇨유발쥐를 사용하여 참께함유 항산화성분인 sesamin과 sesamolin의 혈당과 생체내 항산화 방어효소에 미치는 효과에 대하여 알아보고자, 당뇨유발쥐에 0.2% sesamin또는 0.2% sesamolin 함유사료를 3주간 급여하여, 혈당농도, 뇨당농도, 혈청 GOT와 GPT활성, 혈청 및 간조직의 지질과산화물,그리고 GSH함량과 GST활성에 미치는 영향을 조사하였다. STZ투여군의 혈당량은 319.4