Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

General Pharmacology of Head of Panax ginseng Butanol Fraction

인삼노두 Butanol 분획물의 일반약리작용

  • Suh, In-Ok (College of Pharmacy, Duksung Women's University) ;
  • Hyun, Jin-Ee (College of Pharmacy, Duksung Women's University) ;
  • Cho, Sung-Ig (Dept. of Pharmacology, School of Medicine, Ajou University) ;
  • Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
  • 서인옥 (덕성여자대학교 약학대학) ;
  • 현진이 (덕성여자대학교 약학대학) ;
  • 조성익 (아주대학교 의과대학 약리학교실) ;
  • 정춘식 (덕성여자대학교 약학대학)
  • Published : 2002.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Previously, we have reported that the butanol fraction of the head of Panax ginseng had significant gastroprotective activity on gastritis and gastric ulcer models of rats. Considering the safety of the fraction for development of new anti-ulcerative agent or food supplement, general pharmacological study was carried on. The fraction was revealed that have no influence on spontaneous activity, phenobarbital-induced sleeping time, rotarod test, body temperature, gastro-intestinal motility, respiration and blood pressure. The fraction showed weak analgesic action in writhing syndrome and did not show any sign of acute toxicity in mice.

Keywords

References

  1. 허 준(1989),동의보감,남산당 편,서울
  2. Jeong, C. S., Jung, K. H., Lee, E. B. (1996) Antigastridc and antiulcer actions of the extract of head of Panax Ginseng Radix. Kor. J. Pharmacogn. 27(4): 295-300
  3. Jeong C. S. (2002) Effect of butanol fracdon of Panax ginseng head on gastric lesion and ulcer. Arch. Pharm. Res. 25(1): 61-65 https://doi.org/10.1007/BF02975263
  4. Irwin, S. (1968) Comprehensive observational assessment: la. A systematic quantitative procedure for assessing the behavioral physiologic state of the mouse. Phychophar-macologia 12: 222-257
  5. Kato, H., Susuki, S., Nakao, K., Lee, E. B. and Takagi, K. (1973) Vasodilating effect of Crude platycodin in anesthetized dog. Jpn. J. Pharmacot. 23: 709 https://doi.org/10.1254/jjp.23.709
  6. Dunham, N. W., Miya, T. S. and Edwards, C. D. (1957) Pharmacological activity of a series of basic esters of mono-and dialkyl malonic acid. J. Am. Pharmcol. Assoc. 46: 208 https://doi.org/10.1002/jps.3030460322
  7. Koster, R., Anderson, M. and Beer, E. J. (1959) Acetic acid for Anafesic and screening. Fed Proc. 18: 412
  8. Takemori, A. E., Kupferberg, H. T. and Miller, J. W. (1969) Quantitative studies of antagonism of morphine by nalorphine and naloxone. J. Pharmacol. Exp. Ther. 169: 39-45