Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibitory Activity of Plant Extracts on Matrix Metalloproteinase-2

식물추출물의 Matrix Metalloproteinase-2에 대한 저해활성

  • Lee, Sang-Myung (Korea Research Institute of Bioscience and Biotechnology) ;
  • Chun, Hyo-Kon (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Ho-Jae (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Choong-Hwan (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Jin-Hee (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kho, Yung-Hee (Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2002.06.30
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Abstract

The inhibitory effects of methanol extracts of 165 medicinal herbs on matrix metalloproteinase-2 (MMP-2) activity were investigated. Amongst the herbal extracts, Youngia denticulate, Platycarya strobilacea, Sedum kamtschaticum, Euscaphis japonica, and Comus controversa showed a significant inhibitory effect with above 80% at $1\;{\mu}g/ml$. Above mentioned five kind extracts, which exclude polyphenols and/or tannin by techniques for their removal, showed a mild inhibitory effect on MMP-2 activity except for Y. denticulate at the same concentration.

Keywords

References

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