Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Radical Scavenging Activity from the Marine-Derived Fungus

해양균류의 라디칼 소거활성 검색

  • Li, Xi Feng (Department of Chemistry, Pukyong National University) ;
  • Li, Yong (Department of Chemistry, Pukyong National University) ;
  • Nam, Ki-Wan (Department of Marine Biology, Pukyong National University) ;
  • Kim, Dong-Soo (Department of Food Science and Technology, Kyungsung University) ;
  • Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
  • Published : 2002.09.30
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Abstract

In order to screen new radical scavenging principle which is expected to be antiaging drug lead, we have isolated 160 strains of the marine-derived fungi and investigated 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity for their acetone extracts. The significant activities (>50% Inhibition) were observed in 8 strains of fungi (MFA006, MFA0l4, MFA040, MFA133, MFA139, MFA143, MFA148, MFA153), and among them, MFA153 (Aspergillus parasiticus) showed the most significant radical scavenging activity. The active components were purified by assay-guided isolation to yield two known benzyl alcohols, l53B3 (1) and l53B4 (2), and their structures were determined by physicochemical evidence. Two compounds (1,2) showed the significant radical scavenging activity with $IC_{50}$ values of 0.6 and $1.4{\mu}M$ against DPPH, respectively.

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References

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