Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effects of Taste and Quality of Drugs on the Plasma Corticosterone Level in Mice exposed to Heat and Cold Stress

한약(韓藥)의 기미(氣味)가 한열자극(寒熱刺戟)을 받은 생쥐의 혈중(血中) corticosterone에 미치는 효과(效果)

  • Nam Yeo-Jeong (Department of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University) ;
  • Lee Tae-Hee (Department of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University)
  • 남여정 (경원대학교 한의과대학 방제학교실) ;
  • 이태희 (경원대학교 한의과대학 방제학교실)
  • Published : 2002.06.20
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Abstract

This study was performed to investigate what effect the taste and quality of drugs would have on the cold and heat mechanisms of human body. We administered Hwangryeunhaedok-tang composed of bitter-tasted, cold-qualified drugs and Gungangbuza-tang composed of spice-tasted. hot-qualified drugs, respectively to the mice 1 hr before exposure to heat stress or cold stress. Plasma corticosterone level of mice was measured. The results were as follows: 1. The elevated corticosterone level in the mice exposed to heat stress was significantly decreased after administration of Gungangbuza-tang but there was no decrease after administration of Hwangryeunhaedok-tang. 2. The elevated corticosterone level in the mice exposed to cold stress was significantly decreased after administration of Hwangryeunhaedok-tang but there was mild decrease after administration of Gungangbuza-tang. 3. When the doses, 3g/kg and 1g/kg were administerd to mice exposed to heat stress. both dose showed significant decrease of corticosterone level and the dose. 3g/kg was more effective. However, in the mice exposed to cold stress, the dose, 3g/kg showed mild decrease and 1g/kg showed significant decrease. These data suggested that HW decreased the plasma corticosterone level in the mice exposed to cold stress and GB also decreased the plasma corticosterone level in the mice exposed to heat stress. In conclusion, our study revealed that the taste and quality of drugs controled the cold and heat mechanism of human body.

Keywords

References

  1. 黃帝內經素問 王氷
  2. 東醫臨床方劑學 尹吉榮
  3. 本草備要解析 楊東喜
  4. 東醫學의 方法論 硏究 尹吉榮
  5. 圖說漢方診療要方 李載熙
  6. 傷寒論 症狀鑑別綱要 吳元黔;陳國信;郭秀琴;劉明義;羅江허(共編著)
  7. 예白叢書 v.1 東醫診斷學 李文宰
  8. 현대환경위생학 朴良元(外)
  9. Endocrinology v.110 Pituitary-adrenal function in rats chronically exposed to Cold Vernikos, J.;Dallman, M.F.;Bonner, C.;Katzen, A.;Shinsako, J.
  10. The nature of adaptive reaction and their initiation Chander(etc.)
  11. 本草學 全國韓醫科大學 本草學敎授 共編(著)
  12. 東醫病理學 文濬典;安圭錫;崔昇勳
  13. 本經疏證 v.上;下 임진석
  14. 中藥學 林通國(主編)
  15. 傷寒論譯詮 蔡仁植
  16. 東洋醫學 診療要鑑 金定濟
  17. 現代韓方講座 朴盛洙;廉泰煥
  18. 동의학총서 v.6 동의처방학 조선의학과학원 동의학연구소 고전연구실(編著)
  19. 응급의학 이한식(외10인)
  20. 예방의학과 공중보건 예방의학과 공중보건 편집위원회 최삼섭(외52명)
  21. 생리학 이상돈(外)
  22. 임상 내분비학 민헌기
  23. 백서의 고온적응에 미치는 생맥산과 육일산의 영향에 관한 연구 최보업
  24. 校訂 方劑大辭典 江克明;包明蕙
  25. Physiology of man in the desert Adolf, E.F.
  26. Fed. Proc. v.22 Optical exposure time for development of acclimatization to Heat Lind, A.R.;Bass, D.E.
  27. Ann. J. Physiol. v.139 Cardiovascular adjustments of man in rest and work during exposure to dry Heat Taylor, H.L.;Henschel, A.F.;Key, A.
  28. Heat and Cold effects and their control, Public health monograph. Duglas, H.K.
  29. Fed Prod. v.40 Hypothamic mechanisms in thermoregulation . Boulant, J.A.
  30. Neuroendocrinoloy v.71 Acute-Stress-Induced Facilitation of the hypothalamic-Pituitary-Adrenal Axis Y. Nancy Wong;William J. Cassano Jr.;Anil P.D'mello
  31. Endocrinology v.117 Corticotropin-releasing factor stimulation of adrenocorticotropin and $\beta$-endorpin release:Effect of acute chronic Stress Young, E.A.;Akil, H.
  32. Brain Res. v.532 GRF Receptor regulation and sensitization of ACTH responses to acute ether Stress during chronic intermittent immobilization Stress Hauger, R.L.;Lorang, M.;Irwin, M.;Aguilera, G.
  33. Neuroendocrinology v.56 Desensitization of the HPA axis following prolonged administration of corticotropin-releasing hormone or vasopressin Tizabi, Y.;Aguilera, G.
  34. Endocrinology v.113 Influence of the frequency of oCRF administration on ACTH and Corticosterone secretion in the rat River, C.L.;Vale, W.W.
  35. Endocrinology v.91 Corticosteroid feedback control of ACTH seretion: Rapid effects of bilateral adrenalectomy on plasma ACTH in the rat Dallmann, M.F.;Jones, M.T.;Vemikos-Danellis, J.;Gangong, W.F.
  36. Endocrinology v.91 Failure to detect excessive Stress-induced adrenal Cortcosterone secretion following aminoglutethimide with deawal in the rat. Greer, M.A.;Allen, C.F.
  37. Endocrinology v.97 Increased rate of response of the pituitary-adrenal system in rats adapted chronic Stress Sakellaris, P.C.;Vernilos-Danellis, J.
  38. Neuroendocrinology v.60 Direct evidence for chronic Stress-induced facilitation of the adrenocorticotropine response to a novel acute Stressor Marti, O.;Gacalda, A.;Gomez, F.;Armario, A.
  39. Cell. Mol. Neubiol. v.13 Regulation of adrenocorticosteroid receptor mRNA expression in the central nervous system Herman, J.P.
  40. Arch. Inten. Med. v.153 Stress and the indiviual;Mechnisms leading to disease McEwen, B.S.;Stellar, E.
  41. Am. J. Psychiat. v.146 Pathophysiology of HPA axis abnormalities in patients with major depression: an update Kathol, R.G.;Jaeckle, R.S.;Lopez, J.F.
  42. Endocrinology v.123 Corticotropin releasing factor receptors and pituitary-adrenal responses during immobilization Stress Hauger, R.L.;Millan, M.A.;Lorang, M.;Harwood, J.P.;Aguilera, G.