Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지
DOI QR코드

DOI QR Code

The Effects of Sedum sarmentosum Bunge on Serum Lipid Concentration in Ovariectomized Rats

돌나물이 난소 절제한 흰쥐의 혈 중 지질 함량에 미치는 영향

  • 김원희 (신라대학교 식품영양학과) ;
  • 배송자 (신라대학교 식품영양학과) ;
  • 김미향 (신라대학교 식품영양학과)
  • Published : 2002.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this study was to investigate in an in vivo model the effects of ethanol extract and ethyl ether and ethyl acetate fractions of Sedum sarmentosum Bunge (SS). To investigate the effects of ethanol extract and ethyl ether and ethyl acetate fractions, Sprage-Dawley female rats were randomly assigned to groups as follows : Sham, OVX-control and ovariectomized rats supplemented with SS at 50 mg/kg bw/day, with SS at 100 mg/kg bw/day, with SS at 200 mg/kg bw/day, with ethyl ether fraction of SS at 10 mg/ka bw/day and with ethyl acetate fraction of SS at 10 mg/kg bw/day. Food intake and food efficiency ratio were not significantly different in groups. But body weight gain was decreased by supplementation of ethyl acetate fraction of SS compared to OVX-control. The levels of total cholesterol and triglyceride in serum were higher in ovariectomized control rats than Sham-operated rats, but supplementation of SS ethanol extracts at 200 mg/kg bw/day decreased the level of the lipid in serum. The level of HDL-cholesterol in serum increased by supplementation of SS ethanol extracts at 200 mg/kg bw/day (p<0.01). The levels of total cholesterol and triglyceride in serum were decreased by supplementation of ethyl acetate fraction of SS (p<0.01). On the other hand, the level of HDL-cholesterol in serum was increased by supplementation of ethyl acetate fraction of SS (p<0.05). On conclusion, it might be expected that ethanol extract and ethyl acetate fraction of SS is believed to be a possible protective effects for the fatty serum increasing serum lipid.

본 연구에서는 인위적 폐경을 유발시킬 수 있는 난소 절제 쥐에서와 돌나물 에탄을 추출물과 분획물의 혈 중 지질 함량 변화에 미치는 영향을 검토하였다. 난소 절제로 인해 야기되는 혈중 콜레스테를 함량의 증가는 돌나물 추출물 및 ethyl acetate 분획물의 투여에 의해 감소하는 경향이 나타났다. 혈중 중성지방 농도에서도 돌나물 분획물 투여가 유의적 감소 효과를 나타내었다. 한편, 혈 중 HDL-콜레스테를 함량은 난소 절제군에 비해 난소 절제 후 ethyl acetate 분획물을 투여한 군에서 그 수치가 유의적으로 증가 하였고, Sham군에 비해 오히려 더 증가하는 경향을 나타내었다. 혈중 중성지방 농도에서도 돌나물 분획물 투여가 유의적 감소 효과를 나타내었다. 돌나물 추출물과 분획물이 에스트로겐 감소로 인한 혈중 지질 대사에 효과를 나타낸 본 실험 결과를 미루어 보아, 돌나물 중의 에스트로겐 유사 효과를 나타내는 phytoestrogen이 있을 것으로 추론되고 이로 인해 외인성 에스트로겐 투여로 인한 부작용을 줄여 줄 수 있을 것으로 기대된다. 이상과 같은결과는 돌나물의 섭취가 폐경기 여성에게 폐경기 증상의 호전 및 순환계질환의 위험도를 감소시킬수 있을것으로 사료되어진다.

Keywords

References

  1. http://omworld.com/hanbang/jeng-yungi.htm
  2. National Statistical Office. 1997. Annual report on the cause of death statistics. Seoul.
  3. Belchetz PE. 1994. Hormonal treatment of postmenopausal women. N Eng J Med 330: 1062-1071. https://doi.org/10.1056/NEJM199404143301508
  4. Kim JH, Joun SM, Park YA, Choi MS, Moon KD. 1999. Effects of safflower seed (Carthamus tinctorius L.) powder on lipid metabolism in high fat and high cholesterol-fed rats. J Korean Soc Food Sci Nutr 28: 625-631.
  5. Gordon T, Kannel WK, Hjortl MC. 1978. Menopause and coronary heart disease. Ann Int Med 89: 157-161. https://doi.org/10.7326/0003-4819-89-2-157
  6. Jung YT. 1994. Human Psysiology. 3rd revised. Chungku Press, Seoul. p 383-414.
  7. Preuss HG. 1993. Nutrition and diseases of women: Cardiovascular disorders. J Am Coll Nutr 12: 417-425. https://doi.org/10.1080/07315724.1993.10718331
  8. Ross RK, Pagamm-Hill A, Mark TM, Henderson BE. 1989. Cardiovascular benefits of estrogen replacement therapy. Am J Obstet Gynecol 160: 1301-1306. https://doi.org/10.1016/S0002-9378(89)80017-1
  9. Campos H, Wilson Peter WF, Jimenez D, Mcnamara JR, Ordovas J, Schaefer EJ. 1990. Differences in apolipoproteins and low density lipoprotein subfractions in postmenopausal women on and off estrogen therapy: Results from the Framingham offspring study. Metabolism 39: 1033-1038. https://doi.org/10.1016/0026-0495(90)90162-6
  10. Reinli K, Gladys B. 1996. Phytoestrogen content of foods: A compendium of literature values. Nutrition and Cancer 26: 123-148. https://doi.org/10.1080/01635589609514470
  11. Fanti P, Monier-Fauagere MC, Geng Z, Schmit J, Morris PE, Coren D, Malluche HH. 1988. The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporosis Int 8: 274-281. https://doi.org/10.1007/s001980050065
  12. Bingham PE. 1998. Hormonal treatment of postmenopausal women. N Eng J Med 330-406.
  13. Fukutake M, Takahash M, Ishida K, Kawamura H, Sugimura T, Wakabayashi K. 1996. Quantification of genistein and genistin in soybeans and soybean products. Food and Chemical Toxicology 34: 547-461. https://doi.org/10.1016/0278-6915(96)87355-8
  14. Herman A, Witold M. 1997. Phytoestrogens and Western diseases. Annals of Medicine 29: 95-120. https://doi.org/10.3109/07853899709113696
  15. Irvine CHG, Pitzpatrick NG, Alexander SL. 1998. Phytoestrogens in soy-based infant foods, concentration, daily intake, and possible biological effects. Proc Soc Exp Biol Med 217: 247-253. https://doi.org/10.3181/00379727-217-44229
  16. 김희연. 1999. 천연식품 중의 내분비계 장애 물질에 대하여. 식품과학과 산업 32: 43-50.
  17. 윤국병, 장준근. 1992. 몸에 좋은 산야채. 석오출판사, 서울. p 376.
  18. 윤국병, 장준근. 1990. 맛있는 산나물 100선. 석오출판사, 서울. p 132.
  19. 정태현. 1965. 한국동식물도감. 제5권. 식물편(목초본류). 삼화출판사발행, 서울. p 470.
  20. 이덕봉. 1974. 한국동식물도감. 제15권. 식물편(유용식물). 삼화서적주식회사, 서울. p 206.
  21. 송주택, 김태정. 1988. 한국 야생화 도감. 교학사. p 116.
  22. 안덕균. 1993. 가정 동의보감. 여강출판사, 서울. p 272.
  23. 김상애. 1996. 개정 새식품성분표. 부산여자대학교출판부, 부산. p 68.
  24. Kang BK, Hwang SJ, Paik DJ, Kim JK, Chung HS. 1997. A morphological study on ossification of callus after rib fracture in ovariectomized and estrogen-retreated rats. Hanyang J Med 17: 82-91.
  25. Kind PRN, King EJ. 1954. Estimation of plasma phosphatase by determination of hydrolyzed phenol with aminoantipyrine. J Clin Pathol 7: 322-326. https://doi.org/10.1136/jcp.7.4.322
  26. Reitman S, Frankel S. 1963. A colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am J Clin Pathol 28: 56-61.
  27. Wronski TJ, Cintron M, Dann LM. 1988. Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif Tissue Int 43: 179-183. https://doi.org/10.1007/BF02571317
  28. Abe T, Chow JWM, Lean JM, Chambers TJ. 1993. Estrogen does not restore bone lost after ovariectomy in the rat. J Bone Miner Res 8: 831-838. https://doi.org/10.1002/jbmr.5650080709
  29. Aitken JM, Armstrong E, Anderson JB. 1972. Osteroporosis after ophoretomy in the mature female rat and the effect of estrogen and/or progesterone replacement therapy in its prevention. J Endocrinol 55: 79-87. https://doi.org/10.1677/joe.0.0550079
  30. Sorva R, Kuusi T, Dunkel L, Taskmen MR. 1988. Effects of endogenous sex steroids on serum hypoproteins and posthepann plasma hypolytic enzymes. J Clin Endocrinol Metab 66: 408-413. https://doi.org/10.1210/jcem-66-2-408
  31. Baker HJ, Lindsey JR, Weisbroth SH. 1984. The laboratoty rats. Academic Press Inc, New York. Vol II, p 123-127.
  32. The Association of Korean Clinical Pathology. 1994. The clinical pathology. Korea Medicine Co, Seoul. p 40-79.
  33. Kim IG, Kim SB, Kim JG, Kim KC. 1993. Serum enzymes as indicators of radiation exposure in rat. J Korean Karp 18: 37-44.
  34. Koh JB, Choi MA. 1999. Effect of tea fungus/kombucha on lipid metabolism in streptozotocin-induced diabetic male rats. J Korean Soc Food Sci Nutr 28: 613-618.
  35. Cho EJ, Lee BS, Jeong CJ, Lim YG, Cha DH, Park KH, Cho DJ, Lee K, Song CH. 1995. The effect of postmenopausal hormone replacement therapy on serum Lipoprotein (a) concentration. Korean Soc Obstetrics & Gynecology 38: 1253-1257.
  36. Lee SY, Lee SH, Kie BS. 1996. A study on psychological strain in menopausal women. Korean Soc. Obstetrics & Gynecology 39: 555-561.
  37. Lichtman R. 1991. Perimenopausal hormone replacement therapy. J Nurse Midwifery 36: 30-48. https://doi.org/10.1016/0091-2182(91)90019-L

Cited by

  1. Antibacterial Activity and Protective Role against Gastric Cancer by Sedum sarmentosum vol.55, pp.3, 2012, https://doi.org/10.3839/jabc.2012.024
  2. Effects of Kangjieum on Serum Lipids and Active Oxygen Content in Overweight Women Consequential Qi-stagnation and Blood Stasis Patterns vol.25, pp.4, 2012, https://doi.org/10.9799/ksfan.2012.25.4.697
  3. Antimicrobial Activity on Respiration Diseases Inducing Bacteria and Antioxidant Activity of Water Extracts from Wild Edible Vegetables vol.27, pp.2, 2012, https://doi.org/10.7841/ksbbj.2012.27.2.114
  4. 초임계 이산화탄소를 이용한 돌나물 추출물이 사염화탄소로 유발된 흰쥐의 지질대사, 지질과산화 및 항산화에 미치는 영향 vol.21, pp.3, 2004, https://doi.org/10.12925/jkocs.2004.21.3.3
  5. 한약자원을 이용한 약선차의 영양성분 분석 및 약선차의 섭취가 여대생의 혈청지질수준과 호모시스테인 농도에 미치는 효과 vol.35, pp.5, 2002, https://doi.org/10.3746/jkfn.2006.35.5.557