Korean Journal of Materials Research (한국재료학회지)

Materials Research Society of Korea (한국재료학회)
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Preparation of Photosensitizer-Coated Ferrofluids and Fabrication of a Device for Photodynamic Therapy

광감제가 코팅된 자성유체의 제조와 광역학 치료용 장치의 구성

  • Gwon, Sun-Gwang (Division of Materials Engineering, Chungnam National University) ;
  • Kim, Jong-O (Division of Materials Engineering, Chungnam National University) ;
  • Kim, Jong-Hui (Research Center for Advanced Magnetic Materials)
  • 권순광 (충남대학교 공과대학 재료공학과) ;
  • 김종오 (충남대학교 공과대학 재료공학과) ;
  • 김종희 (고기능성자성재료연구센터)
  • Published : 2002.03.01
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Abstract

For the purpose of annihilating tumor in body, hematoporphyrin as a photosensitizer was coated onto magnetic particles of $Fe_3O_4$ prepared by coprecipitation which could be concentrated around the tumor by magnetic field. The photosensitizer was applied differently before, during and after adsorbing the 1st surfactant on the particles. Its added amount was $5{\times}10^{-4}/mol$, and the coating reaction proceeded at temperatures of 60, 70 and 8$0^{\circ}C$. The amounts of photosensitizer coated on the magnetic particles were obtained by calculating an optical density with the maximum UV spectrum. As a result of the UV analysis, the coating amount of photosensitizer increased with higher reaction temperatures. When applied at 8$0^{\circ}C$ after adsorbing the 1st surfactant, the photosensitizer was coated with a maximum value of $3.8{\times}10^{-3}/mo1/$\ell$$. The TGA analysis revealed that the ferrofluids included the particles of 30.115 g/$\ell$. It was suggested that the magnetite particles was coated with photosensitizer of $1.26{\times}10^{-4}/mo1/g$. A small-sized device for magnetic field and light emission was designed, in which LED sheets coverts the permanent magnet of Nd-Fe-B. The LED sheet was connected in series circuit and also protected with a silicon tube. The power was supplied with rechargable battery of 9V and 100-120mA.

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