Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Inhibitory Activity of Diacylglycerol Acyltransferase by Tanshinones from the Root of Salvia miltiorrhiza

  • Ko, Jeong-Suk (Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Ryu, Shi-Young (Korea Research Institute of Chemical Technology) ;
  • Kim, Young-Sup (Korea Research Institute of Chemical Technology) ;
  • Chung, Mi-Yeon (Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kang, Jong-Seong (College of Pharmacy, Chungnam National University) ;
  • Rho, Mun-Chual (Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyun-Sun (Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Young-Kook (Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2002.08.01
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Abstract

The inhibitory activity of tanshinones from Salvia miltiorrhiza was tested on rat liver diacylglycerol acyltransferase (DGAT). Cryptotanshinone (1) and 15,16-dihydrotanshinone I (3) exhibited potent DGAT inhibitory activities dose-dependently with $IC_{50}$ values of $10.5 {\;}{\mu\textrm{g}}/ml{\;}and{\;}11.1{\;}{\mu\textrm{g}}/ml$. However, tanshinone IIA (2) and tanshinone I (4) showed very weak inhibition ($IC_{50}{\;}value:{\;}>{\;}250{\;}{\mu\textrm{g}}/ml$). A dihydrofuran moiety was seemed to be responsible for the stronger inhibitory activity

Keywords

References

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