Korean Journal of Oriental Medicine (한국한의학연구원논문집)
- Volume 9 Issue 2
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- Pages.107-119
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- 2003
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- 1229-3377(pISSN)
Efficacy Study of Kami-honghwa-tang on the Reduction of Side Effects of Radiotherapy
가미홍화탕의 방사선 부작용 억제 효능연구
- Moon, Geun-Ah (Korea Institute of Oriental Medicine) ;
- Song, Nak-Geun (Korea Institute of Oriental Medicine) ;
- Park, Seong-Jin (Korea Institute of Oriental Medicine) ;
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Yoon, Yoo-Sik
(Korea Institute of Oriental Medicine)
- Published : 2003.12.30
Abstract
In this study, Kami-honghwa-tang (KH-19) was designed and animal study was conducted to evaluate its efficacy on the reduction of the side effect of radiotherapy. Bone marrow toxicity is one of the major side effect of radiotherapy which cause the reduction of blood cells, and KH-19 was designed to protect and enforce blood. C57BL/6 mice were irradiated with 4 Gy of gamma ray, and divided into control group which was treated with water and KH-19 group which was treated with 1.5g/Kg of KH-19 up to 4 weeks. KH-19 group showed significantly increased white blood cells, lymphocytes and platelet count compared with control group (p<0.05). When bone marrows were examined, KH-19 group showed higher cell densities than control group (p=0.06). KH-19 may increase blood cell count after radiation by its protective effects on bone marrow.