Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Differences of Hematopoietic Effects of Angelica gigas, A. sinensis and A. acutiloba Extract on Cyclophosphamide-induced Anemic Rats

한국.중국.일본 당귀가 cyclophosphamide로 유발된 흰쥐의 빈혈에 미치는 영향의 차이

  • Kang, Soon-Ah (Bio/Molecular Informatics Center, Department of Molecular Biotechnology, Konkuk University) ;
  • Jang, Ki-Hyo (Department of Food and Nutrition, Samcheok National University) ;
  • Lee, Ji-Eun (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Ahn, Duk-Kyun (Jaseng Research Institute of Biotechnology and Bioscience) ;
  • Park, Seong-Kyu (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
  • 강순아 (건국대학교 분자생명공학전공 생명/분자정보학센터) ;
  • 장기효 (삼척대학교 식품영양학과) ;
  • 이지은 (경희대학교 한의과대학 방제학교실) ;
  • 안덕균 (자생생명공학연구소) ;
  • 박성규 (경희대학교 한의과대학 방제학교실)
  • Published : 2003.12.01
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Abstract

The purpose of this study was to compare the hematopoietic effects of Angelica gigas, A. sinensis, and A. acutiloba extract (1 g/kg B.W.) on cyclophosphamide-induced (30 mg/kg B.W.) anemic rats. Cyclophosphamide injection group (AG, AS, AA) showed a decrease in weight gain in comparison with the normal group. Compared to the cyclophosphamide-treated control group, oral administration of Angelica gigas extract for 14 days in the normal group significantly prevented body weight loss. The iron level of the A. gigas-administered group was significantly higher than the control groups. The serum vitamin $B_{12}$ level of A. gigas-, A. sinensis-, and A. acutiloba-administered groups was significantly higher than in the control. We suggest that administration of A. gigas, A. sinensis, and A. acutiloba prevents cyclophosphamide-induced anemia by improving hematological value and iron status.

항암제인 cyclophosphamide를 흰쥐에 투여하여 유발된 빈혈증상에 대하여 한국당귀, 중국당귀, 일당귀의 투여가 빈혈회복에 미치는 효능을 비교한 연구로서, Sprague-Dawley계 수컷 흰쥐에게 cyclophosphamide를 30mg/kg BW/day로 3회 복강 투여 후, 참당귀, 중국당귀와 일당귀 추출물을 1 g/kg BW/day로 14일 동안 경구 투여하였다. Cyclophosphamide 투여로 체중감소는 대표적인 전신증상으로 나타났으나 당귀추출물의 투여가 cyclophosphamide에 의한 체중감소 부작용을 저해함으로써 체중증가를 유도한 것으로 볼 수 있다. 참당귀 투여군은 적혈구 용적(hematocrit, Hct) 변화, 적,백혈구수 변화, 혈색소 농도 변화, 혈청 iron, transferrin 포화도 등의 항목에 대하여 유의성 있는 회복 효과를 나타내었고, 중국 및 일당귀 투여군은 백혈구수 감소에 대하여 유의성 있는 회복효과를 나타내었다. Cyclophosphamide 투여 후 비타민 $B_{12}$ 농도는 정상군에 비해 유의적으로 낮았고, 중국당귀, 참당귀, 일당귀 순으로 비타민 $B_{12}$ 농도가 유의적으로 증가하는 것을 관찰하였다. 이는 당귀가 비타민 $B_{12}$의 농도를 증가시키면서 혈액생산작용에 도움을 줄 것으로 여겨진다. 결론적으로 참당귀추출물 투여로 인해 혈액수치가 향상된 결과는 암 환자가 화학요법으로 인하여 생긴 빈혈치료에 도움이 될 것이라 생각된다.

Keywords

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