Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Experimental Study of Acupuncture at Haenggan(LR2) on the Cerebral Hemodynamics in Normal Rats

행간(行間) 자침(刺鍼)이 뇌혈류역학(腦血流力學) 작용(作用) 기전(機轉)에 미치는 실험적(實驗的) 연구(硏究)

  • Lee Yoon-Yeong (Dept. of Acupunture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Na Chang-Su (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Ryu Chung-Ryul (Dept. of Acupunture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Cho Myeng-Rae (Dept. of Acupunture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Shin Jeong-Chul (Dept. of Acupunture & Moxibustion, College of Oriental Medicine, Dongshin University)
  • 이윤영 (동신대학교 한의과대학 침구학교실) ;
  • 나창수 (동신대학교 한의과대학 경혈학교실) ;
  • 유충렬 (동신대학교 한의과대학 침구학교실) ;
  • 조명래 (동신대학교 한의과대학 침구학교실) ;
  • 신정철 (동신대학교 한의과대학 침구학교실)
  • Published : 2003.12.27
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Abstract

Objectives : The purpose of this study is to investigate whether Haenggan(LR2) Reduction in Acupuncture affects cerebral hemodynamics〔regional cerebral blood flow(rCBF), mean arterial blood pressure(MABP)〕in normal rats, and to make manifest whether Haenggan(LR2) Reduction in Acupuncture is mediated by cyclooxygenase or guanylate cyclase. Methods : This experiments was to investigate at the other changes of rCBF and MABP at Haenggan(LR2) Reduction in Acupuncture in normal rats, pretreated rats with indomethacin(1 mg/kg, i.v.) and pretreated rats with methylene blue$(10\;{\,u}g/kg,\;i.v.)$. Results : 1. Haenggan(LR2) Reduction in Acupuncture was significantly increased rCBF during acupuncture and after withdrawing of the needle. 2. Haenggan(LR2) Reduction in Acupuncture was decreased MABP during acupuncture, but Haenggan(LR2) Reduction in Acupuncture was increased MABP in compared with normal condition. 3. Pretreatment with indomethacin(1 mg/kg, i.v.) was significantly inhibited Haenggan(LR2) Reduction in Acupuncture induced increase of rCBF, but was increased Haenggan(LR2) Reduction in Acupuncture induced increase of MABP. 4. Pretreatment with methylene blue$(10\;{\mu}g/kg,\;i.v.)$ was significantly decreased Haenggan(LR2) Reduction in Acupuncture induced increase of rCBF and MABP. This results suggest that Haenggan(LR2) Reduction in Acupuncture increased rCBF by dilating pial arterial diameter, and the mechanism of Haenggan(LR2) Reduction in Acupuncture is mediated by guanylate cyclase.

Keywords

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