Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
권호 표지
DOI QR코드

DOI QR Code

A Study on Preventive Effect of Ginseng on All Cause Mortality -Kangwha Cohort Study-

인삼의 사망에 대한 예방효과에 관한 연구

  • Yi, Sang-Wook (Department. of Preventive Medicine and Public Health, Kwandong University College of Medicine) ;
  • Hong, Jae-Suk (Department of Preventive Medicine and Public Health, Yonsei University College of Medicine) ;
  • Ohrr, Hee-Choul (Department of Preventive Medicine and Public Health, Yonsei University College of Medicine)
  • 이상욱 (관동대학교 의과대학 예방의학교실) ;
  • 홍재석 (연세대학교 의과대학 예방의학교실) ;
  • 오희철 (연세대학교 의과대학 예방의학교실)
  • Published : 2003.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Recently, there are much concerns about ginseng as disease therapeutics. There are no epidemiologic study on relationship between ginseng intake and all cause mortality based from general population Cohort. This study sought to examine relationships between ginseng intake and all cause mortality from Kangwha Cohort data. From March 1985 through December 1999, 2696 males and 3595 females who were aged 55 or over as of 1985 were followed up. We calculate the mortality rate, standardized mortality ratio and risk ratios by ginseng intake. Cox proportional hazard model was used to adjust various confounding factors. Ginseng intake group had the lower all cause mortality(Risk ratio(RR)=0.88, 95%Confidence Interval(CI)=0.79-0.97) among males. Increasing ginseng intake, lower all cause mortality(Low ginseng intake: RR=0.88, 95%CI=0.79-0.98; high ginseng intake : RR=0.87, 95%CI=0.75-1.00) among males. There is no statistically significant difference between ginseng intake and mortality among females. The results of this study suggests that ginseng intake may prolong the human life among males.

Keywords

References

  1. 남기열, 고려인삼의 주오 효능과 그 임상적 응용. : J. Ginseng Res. 26(3), 111-31 (2002) https://doi.org/10.5142/JGR.2002.26.3.111
  2. Chen, X. and Lee, T. J.: Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br. J. Pharmacol. 115, 15-8 (1995) https://doi.org/10.1111/j.1476-5381.1995.tb16313.x
  3. Jin, S. H., Park, J. K., Nam, K .Y., Park, S. N. and Jung, N. P.: Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatril saponin improve scopolamine- induced learning disability and spatial working memory in mice. J. Ethnopharmacil. 66, 123-9 (1999) https://doi.org/10.1016/S0378-8741(98)00190-1
  4. 곽인평. 인삼알콜추출물이 정상 및 자발성고혈압 쥐의 혈관 평활근의 수축에 미치는 영향. : 연세대학교 대학원 박사학 위논문, (1988)
  5. Hikokichic, O., Hia, S., Odaka, Y., and Yokozawa, T.: Studies on the biochemical action of ginseng saponin. I. purification from ginseng extract of the active component stimulating serum protein bioslynthesis. J Biochem. 77, 1057 (1975) https://doi.org/10.1093/oxfordjournals.jbchem.a130806
  6. 김미정, 정노팔.: 생쥐의 면역계에 미치는 인삼 사포 닌의 영향. J. Ginseng Res. 11(2), 130-5 (1987)
  7. Ben-Hur E, and Fulder S. Effect of panax ginseng saponins and eleutherococcus senticosus on survival of cultured mammalian cells after ionizing radiation. Am. j. Complement. Med. 9, 48-56 (1981) https://doi.org/10.1142/S0192415X8100007X
  8. Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Ann Rev Pharmacal. 9, 419 (1969) in:Korea ginseng and tobacco research institute, J. Panax Ginseng 187 (1993)
  9. Singh, V. K., and Agarwal, S. S. : Gupta BM. Immuno-modulatory activity of panax ginseng extract. Pro Abs 4th IntI. Ginseng Symposium, (1984)
  10. Fabio. Immunological studies on ginseng. Pro Abs. 5th IntI. Ginseng Symposium, (1988)
  11. 윤수희. 인삼 사포닌의 고cholesterol혈증 억제작용 메카 니즘에 관한 연구. 연세대학교 대학원 석사학위논문, (1992)
  12. Yun, T. K. and Choi, S.A. : Case-control study of ginseng intake and cancer. Int .J. Epidemiol. 19(4), 871-6 (1990) https://doi.org/10.1093/ije/19.4.871
  13. Yun, T. K, Choi, and S. Y.: Preventive effect of ginseng intake against various human cancers, a case-control study on 1987 pairs. Cancer Epidemioi Biomarkers Prev 4(4), 401-8 (1995)
  14. Yun, T. K. and Choi, S. Y. : Non-organ specific cancer prevention of ginseng, a prospective study in Korea. Int. J. Epidemiol. 27(3), 359-64 (1998)
  15. Ohrr, H. C., Nam, C. M. and Lee, S. H. : A Cohort study on the relationship between pesticide use and mortality, and cancer mortality. Korean J. Prevo Med. (Korean) 24(3), 3909 (1991)
  16. Sahai, H. and Khurshid, A. :Statistics in Epidemiology. Meth ods, Techniques, and Applications. CRC Press, Boca Raton. (1996)
  17. Rothman, K .J., and Greenland, S. : Modern Epidemiology, 2nd ed. . Lippincott Williams &: Wilkins, Philadelphia. (1998)
  18. Szklo, M. and Nieto, F. J. : Epidemiology beyond the basics. Aspen publishers (2002)
  19. Yun, T. K. and Kim, S. H.: Inhibition of develpment of benzo(a)pyrene-induced mouse pulmonary adenoma by natural products medium-term bioassay system. J. Korea Cancer Assoc. 20, 133-42 (1988)
  20. Yun, T. K. : Experimental and epidemiological evidence of the cancer-preventive effects of Panax ginseng C.A. Meyer. Nutr. Rev. 54(11 Pt 2), S71-81 (1996)
  21. Jiang, E, DeSilva, S. and Turnbull, J. : Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice. J. Neurol. Sci. 180(1-2), 52-4 (2000)
  22. Song, Z. J., Johansen, H. K., Faber, V., Hoiby, N. : Ginseng treatment enhances bacterial clearance and decreases lung pathology in athymic rats with chronic P. aeruginosa pneumonia. A.P.M.I.S. 105(6), 438-44 (1997)
  23. Cha, R. J., Zeng, D. W., and Chang, Q. S.: Non-surgical treatment of small cell lung cancer with chemo-radioimmunotherapy and traditional chinese medicine. Zhonghua Nei Ke Za Zhi 33(7), 462-6 (1994)
  24. Han, M. Q., Liu, J. X., and Gao, H. : Effects of 24 chinese medicinal herbs on nucleic acid, protein and cell cycle of human lung adenocarcinoma cell. Zhongguo Zhong Xi Yi Jie He Za Zhi 15(3), 147-9 (1995)
  25. Lin, S. Y., Liu, L. M., and Wu, L. C.: Effects of shenmai injection on immune function in stomach cancer patients after chemotherapy. Zhongguo Zhong Xi Yi fie He Za Zhi 15(8), 451-3 (1995)
  26. Kamei, T., Kumano, H., Iwata, K, Nariai, Y., and Matsumoto, T. The effect of a traditional Chinese prescription for a case of lung carcinoma. J. Altern. Complement. Med. 6(6), 557-9 (2000)
  27. 조항석，오희철，이상욱，이지전，우은경 등. 사망 전 노인들 의 보완대체요법 이용비용과 관련 요인. 제 54차 대한예방 의학회 추계학술대회 연제집. (2002)