Archives of Pharmacal Research

  • 제26권11호
  • /
  • Pages.898-901
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  • 2003
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Diterpenoids from the Stem Barks of Croton robustus

  • Nattya-Ngamrojnavanich (Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University) ;
  • Sorasaree-Tonseiengsom (Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University) ;
  • Preecha-Lertpratchya (lnstitute of Biotechnology and Genetic Engineering, Chulalongkorn University) ;
  • Sophon-Roengsumran (lnstitute of Biotechnology and Genetic Engineering, Chulalongkorn University) ;
  • Songchan-Puthong (lnstitute of Biotechnology and Genetic Engineering, Chulalongkorn University) ;
  • Amorn, Petsom (lnstitute of Biotechnology and Genetic Engineering, Chulalongkorn University)
  • 발행 : 2003.11.01
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초록

Three compounds were isolated from the stem barks of Croton robustus. Their structures were elucidated as trachyloban-19-oic, acid, trachyloban-19-ol and poilaneic acid by spectroscopic analysis. Among them, trachyloban-19-ol and methyl trachyloban-19-oate exhibited weak cytotoxic activity against gastric carcinoma and colon carcinoma with $ED_{50}$ of 9.2, 9.6 and 8.3, $9.1{\mu\textrm{g}}/mL$, respectively.

키워드

참고문헌

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