대한수의학회지 (Korean Journal of Veterinary Research)

  • 제43권1호
  • /
  • Pages.113-120
  • /
  • 2003
  • /
  • 2466-1384(pISSN)
  • /
  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
권호 표지

Staphylococcus aureus에 의한 유방염에 대한 β-lactamase 저해제/β-lactam계 항균제 치료 효과

Antimicrobial effects of β-lactamase inhibitor/β-lactam antibiotics on staphylococcal mastitis

  • Lim, Suk-Kyung (National Veterinary Research & Quarantine Service) ;
  • Lim, Jae-Hhyang (Research Institute of Veterinary Medicine, Chonnam National University) ;
  • Joo, Yi-Seok (National Veterinary Research & Quarantine Service) ;
  • Moon, Jin-San (National Veterinary Research & Quarantine Service) ;
  • Lee, Ae-Ri (Sangmyung University) ;
  • Koh, Hong-Bum (Research Institute of Veterinary Medicine, Chonnam National University)
  • 심사 : 2003.01.03
  • 발행 : 2003.03.31
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초록

The antimicrobial effect of ${\beta}$-lactam antibiotics, which had ${\beta}$-lactamase inhibitor activity, on Staphylococcus aureus isolated from mastitis was investigated in this study. Out of 166 isolates, 99 isolates (59.6%) produced ${\beta}$-lactamase, and 98 isolates of 99 were ${\beta}$-lactamase positive in above $12.5{\mu}g/m{\ell}$ MIC of penicillin. In the providence distribution, ${\beta}$-lactamase production rate of 4 providence, Gangwon, Gyeonggi, Chungcheong, and Jeolla was 100%, 65.7%, 58.8%, and 50.0%, respectively. Antibiotic activities of ${\beta}$-lactam antibiotics against lactamase positive isolates also were investigated. Antimicrobial effects of ampicillin/sulbactam or amoxicillin/clavulanic acid treated group were better than ampicillin or amoxicillin treated group. In antimicrobial effects on intracellular S aureus, there was no difference 1 hour and 4 hour treatment in control, ampicillin, and amoxicillin group, but in 18 hours treatment, ampicillin/sulbactam or amoxicillin/clavulanic acid had a better effect than ampicillin or amoxicillin (p<0.05).

키워드

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