Preventive Nutrition and Food Science

  • 제8권3호
  • /
  • Pages.235-238
  • /
  • 2003
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  • 2287-1098(pISSN)
  • /
  • 2287-8602(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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Effect of Phase Transition Temperature of Phospholipid on the Stability of Retinol Incorporated into Liposomes

  • Lee, Kyung-Eun (Department of Food Science and Biotechnology, Kyungnam University) ;
  • Kim, Jin-Ju (Department of Food Science and Biotechnology, Kyungnam University) ;
  • Yuk, Hyun-Gyun (Department of Food Science and Biotechnology, Kyungnam University) ;
  • Jang, Ji-Young (Department of Food Science and Biotechnology, Kyungnam University) ;
  • Lee, Seung-Cheol (Department of Food Science and Biotechnology, Kyungnam University)
  • 발행 : 2003.09.01
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초록

We investigated the effect of the phase transition temperature (T$_{c}$) of phospholipid in liposomes on the stability of incorporated retinol. Two kinds of phospholipid which have different T$_{c}$, L- $\alpha$ -dimyristoyl phosphatidyl choline (DMPC, T$_{c}$=22$^{\circ}$C) and D,L- $\alpha$ -dipalmitoyl phosphatidyl choline (DPPC, T$_{c}$=42$^{\circ}$), were used to prepare liposomes. Liposome with retinol was prepared as multilamella vesicles (MLVs) by the dehydration/rehydration method. The incorporation efficiency of retinol into liposomes prepared from DMPC and DPPC were 99.89$\pm$0.08% and 99.97$\pm$0.03, respectively. The average size of liposomes from DPPC were greater than that of DMPC. Two kinds of liposomes in phosphate buffer (10 mM, pH 7.0) were stored at 15, 30, and 5$0^{\circ}C$, and stability of incorporated retinol was analyzed. The stability of retinol in DMPC liposome was decreased, whereas the stability in DPPC liposome was increased as temperature increased, although the overall protection effect of liposome on the incorporated retinol was greater in DMPC liposomes than in DPPC liposomes.posomes.

키워드

참고문헌

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  26. Blood v.97 Treatment of newly diagnosed and relapsed acute promyelocytic leukemia with intravenous liposomal all-trans retinoic acid Douer D;Estey E;Santillana S;Bennett JM;Lopez-Bernstein G;Boehm K;Williams T https://doi.org/10.1182/blood.V97.1.73
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  29. Biochim Biophys Acta v.406 The effect of chain length and lipid phase transitions on the selectice permeability properties of liposomes Blok MC;Van der Neut-Kok EC;Van Deenen LL;De Gier J https://doi.org/10.1016/0005-2736(75)90003-6
  30. Biochemistry v.15 Evidence for phase boundary lipid. Permeability of tempo-choline into dimyristoylphatidylcholine vesicles at the phase transition March D;Watts A;Knowles PF https://doi.org/10.1021/bi00661a027
  31. Biochemistry v.26 Temperature dependance of membrane ion conductance analyzed by using the amphiphilic anion 5/6-carbixyfluorescein Bramhall J;Hofmann J;Deguzman R;Montestruque S;Schell R https://doi.org/10.1021/bi00394a006
  32. Biochim Biophys Acta v.1463 Effect of free fatty acids on the permeability of 1,2-dimyristoyl-sn-glycero-3-phospha-tidylcholine bilayer at the main phase teansition Langner M;Hui S https://doi.org/10.1016/S0005-2736(99)00236-9
  33. J Assoc Anal Chem v.59 Colorimetric reagents for determining vitamin A in feeds and foods Subramanyam GB;Parrish DB
  34. Biochemistry v.26 Lipid polymorphism of mixtures of dioleoylphosphatidylethanolamine and saturated and monounsaturated phosphatyidylcholines of various chain lengths Tate MW;Gruner SM https://doi.org/10.1021/bi00375a031
  35. Encapsulation and Controlled Release of Food Ingredients, ACS Symposium Series 590 Lippsomes for controlled release in the food industry Reineccius GA
  36. Liposome Technoloty I Preparation of liposomes on the industrial scale: Problem and perspectives Rao LS;Gregoriadis G(ed.)
  37. Trend in Biotechnology v.16 Nover applocations of liposomes Dan DL https://doi.org/10.1016/S0167-7799(98)01220-7
  38. Zeitschrift fur Naturforschung v.37 Absorption and picosecond fluorescence characteristics of chlorophyll vesicles as a function of temperature Brody SS

피인용 문헌

  1. The Effect of Cholesterol in the Liposome Bilayer on the Stabilization of Incorporated Retinol vol.15, pp.3-4, 2005, https://doi.org/10.1080/08982100500364131