Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지

A comparative study on the osteoporotic animal models in ddY mouse: ovariectomized and neurectomized models

ddY 마우스를 이용한 골다공증 모델에 대한 비교연구: 난소적출 및 신경절단 모델

  • Lee, Hyeung-sik (Department of Herbal Biotechnology, Daegu Haany University) ;
  • Hong, Pyo-one (Department of Herbal Biotechnology, Daegu Haany University) ;
  • Ku, Se-kwang (Pharmacology & Toxicology Lab., Central Research Laboratories) ;
  • Lee, Jae-hyun (Department of Histology, College of Veterinary Medicine, Kyungpook National University) ;
  • Ham, Tae-Su (College of Natural Resources, Yeungnam University)
  • 이형식 (대구한의대학교 한방생명자원학과) ;
  • 홍표원 (대구한의대학교 한방생명자원학과) ;
  • 구세광 (동화약품(주) 중앙연구소 약리독성연구실) ;
  • 이재현 (경북대학교 수의과대학 조직학교실) ;
  • 함태수 (영남대학교 자연자원대학 생물자원학부)
  • Accepted : 2004.09.15
  • Published : 2004.12.30
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Abstract

In order to compare the induced time of osteoporosis between ovariectomized and neurectomized models in ddY mice. Experimental groups were divided into Sham, ovariectomized (OVX group) and neurectomized (NX group) group. The changes of body weight, tibia weight and histomorphometry of epiphyseal regions of tibia that were generally used as criteria index in osteoporosis, were evaluated at 2 and 4 weeks after operations with other generally used index-changes of serum osteocalcin. Also, calcium and phosphorus levels in the ash tibia were demonstrated with their ratio (Ca/P ratio). From the result of this study, evidences which reflect osteoporotic states of animals such as decrease of absolute and relative tibia weight, histomorphometrical index of epiphyseal region of tibia including trabecular bone volume %, and calcium and phosphorous contents in tibia, were generally detected from 4 weeks after ovariectomy and 2 weeks after neurectomy with increase of serum osteocalcin levels. In conclusion, it is considered that more rapid and favorable osteoporosis was induced in neurectomized model compared to that of ovariectomized model.

Keywords

References

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