Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지

A potential role of Schwann cells in spinal nerve roots in autoimmune central nervous system diseases

  • Moon, Changjong (Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University) ;
  • Lee, Yongduk (Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University) ;
  • Shin, Taekyun (Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University)
  • Accepted : 2004.08.16
  • Published : 2004.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

The expression of nestin and vimentin in the spinal nerve roots of rats with experimental autoimmune encephalomyelitis (EAE) was studied to ascertain whether Schwann cells in the peripheral nerves respond to acute central nervous system autoimmune injury. Immunohistochemistry demonstrated that nestin was constitutively expressed in the dorsal roots of spinal nerves in control rats; its expression was enhanced in the spinal nerve roots of rats with EAE. Vimentin expression was weak in control rat spinal nerve roots, and it was increased in the dorsal roots of rats with EAE. It is postulated that normal animals have multipotent progenitor cells that constitutively express nestin and vimentin in the spinal nerve roots. In response to an injury of the central nervous system, these multipotent Schwann cells are activated in the spinal nerve roots through the expression of the intermediate filament proteins vimentin and nestin.

Keywords

References

  1. Calvo, J. L., Carbonell, A. L. and Boya, J. Coexpression of glial fibrillary acidic protein and vimentin in reactive astrocytes following brain injury in rats. Brain Res. 1991, 566, 333-336 https://doi.org/10.1016/0006-8993(91)91720-L
  2. Cammer, W., Tansey, F. A. and Brosnan, C.F. Gliosis in the spinal cords of rats with experimental allergic encephalomyelitis: immunostaining of carbonic anhydrase and vimentin in reactive astrocytes. Glia 1989, 2, 223-230 https://doi.org/10.1002/glia.440020403
  3. Dal Canto, M. C. and Lipton, H. L. Schwann cell remyelination and recurrent demyelination in the central nervous system of mice infected with attenuated Theiler's virus. Am. J. Pathol. 1980, 98, 101-122
  4. Dijkstra, C. D., Dopp, E. A., Joling, P. and Kraal, G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 1985, 54, 589-599
  5. Eliasson, C., Sahlgren, C., Berthold, C. H., Stakeberg, J., Celis, J. E., Betsholtz, C., Eriksson, J. E. and Pekny, M. Intermediate filament protein partnership in astrocytes. J. Biol. Chem. 1999, 274, 23996-24006 https://doi.org/10.1074/jbc.274.34.23996
  6. Moon, C., Kim, S., Wie, M., Kim, H., Cheong, J., Park, J., Jee, Y., Tanuma, N., Matsumoto, Y. and Shin, T. Increased expression of p53 and Bax in the spinal cords of rats with experimental autoimmune encephalomyelitis. Neurosci. Lett. 2000, 289, 41-44 https://doi.org/10.1016/S0304-3940(00)01253-2
  7. Moon, C., Lee, Y. and Shin, T. Immunohistochemical localization of Bcl-2 in the spinal cords of rats with experimental autoimmune encephalomyelitis. J. Vet. Sci. 2002, 3, 279-283
  8. Park, M. S., Lee, J. M., Sim, K. B. and Shin, T. Transplantation of olfactory bulb promote locomotor recovery in dogs with spinal cord hemisection. Korean J. Lab. Anim. Sci. 2003, 19, 271-275
  9. Pender, M. P. Recovery from acute experimental allergic encephalomyelitis in the Lewis rat. Early restoration of nerve conduction and repair by Schwann cells and oligodendrocytes. Brain 1989, 112, 393-416 https://doi.org/10.1093/brain/112.2.393
  10. Raine, C. S. The Dale E. McFarlin Memorial Lecture: the immunology of the multiple sclerosis lesion. Ann. Neurol. 1994, 36, S61-72 https://doi.org/10.1002/ana.410360716
  11. Shin, T., Ahn, M., Jung, K., Heo, S., Kim, D., Jee, Y., Lim, Y. K. and Yeo, E. J. Activation of mitogenactivated protein kinases in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2003, 140, 118-125 https://doi.org/10.1016/S0165-5728(03)00174-7
  12. Shin, T., Kojima, T., Tanuma, N., Ishihara, Y. and Matsumoto, Y. The subarachnoid space as a site for precursor T cell proliferation and effector T cell selection in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 1995, 56, 171-178 https://doi.org/10.1016/0165-5728(94)00144-D
  13. Shin, T., Lee, Y. and Sim, K. B. Embryonic intermediate filaments, nestin and vimentin, expression in the spinal cords of rats with experimental autoimmune encephalomyelitis. J. Vet. Sci. 2003, 4, 9-13
  14. Wei, L. C., Shi, M., Chen, L. W., Cao, R., Zhang, P. and Chan, Y. S. Nestin-containing cells express glial fibrillary acidic protein in the proliferative regions of central nervous system of postnatal developing and adult mice. Brain Res. Dev. Brain Res. 2002, 139, 9-17 https://doi.org/10.1016/S0165-3806(02)00509-6