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당뇨성 흰쥐에서 버섯 추출물 함유 발효유 첨가 식이의 혈당강하작용

Hypoglycemic Effect of Mushroom Fermented Milk in Streptozotocin-Induced Diabetic Rats

  • 발행 : 2004.08.01

초록

버섯 추출물을 첨가하여 유산 발효시킨 버섯발효유와 이때 사용된 버섯 추출물 및 버섯발효유 상등액의 항당뇨 효과를 규명하고자 Sprague-Dawley 수컷에 streptozotocin을 50 mg/kg body weight씩 복강내 주사하여 당뇨를 유발시켜 검토하였다. 버섯발효유, 상등액 및 버섯 추출물을 식이 중에 10% (v/w)씩 동량 첨가 한 식이를 3주간 급여한 후 혈당치, 인슐린 농도 및 경구당부하실험을 실시하였다. 버섯발효유의 이화학적 성분을 분석 한 결과 단백질 2.87%, 지방 0.09%, 탄수화물 6.0%, 식이섬유 0.3%, 락토스 2.01%, 슈크로스 1.23% 및 칼슘과 철 성분을 각각 95.9 및 0.08 mg/l00 g함유하고 있었다. Streptozotocin-유발 대조군 당뇨쥐에 비해 버섯발효유 투여군에서 현저한 혈당강하 효과가 있었으며, 이러한 효과는 인슐린 농도증가에 의한 것으로 나타났다. 또한, 버섯발효유 상등액 및 버섯 추출물에도 혈당강하 효과가 있는 것으로 나타났다. 실험 종료시점에 실시한 경구당부하실험에서도 버섯발효유, 상등액 및 추출물 순으로 현저한 효과를 보였다. 이상의 결과로 볼 때 혈당강하 효과가 있는 버섯과 유산균을 접목한 버섯발효유 제조는 이들 상호간의 시너지 효과에 의해 당뇨성 흰쥐에서 현저한 항당뇨 효과를 발휘하였다.

Nutritional concentrations by chemical analyses of mushroom fermented milk were protein 2.87%, fat 0.09%, carbohydrates 6.0%, dietary fiber 0.3%, lactose 2.01%, sucrose 1.23%, calcium 95.9 mg/100 g and iron 0.08 mg/100 g. The present study was undertaken to investigate the hypoglycemic effects of the equal volume of either water (streptozotocin (STZ)rontrol rats), mushrooms water-extract (STZ-extrart fed rats), mushroom fermented milk product (STZ-mushroom yogurt fed rats) or mushroom fermented milk supernatant (STZ-supernatant fed rats) (10%, v/w), in STZ-induced diabetic rats for 3 week period. The mushroom fermented milk given to the STZ-diabetic rats decreased the blood glucose significantly and increased the blood insulin, compared with the STZ-control rats. The supernatant and mushroom water extract also slightly retarded the development of hyperglycemia in the STZ-diabetic rats. Taken together the results, the mushroom yogurt may have a potential for the hypoglycemic effect in the STZ-diabetic rats.

키워드

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피인용 문헌

  1. Biological Activity of Methanolic Extract from Ganoderma lucidum, Momordica charantia, Fagopyrum tataricum, and Their Mixtures vol.21, pp.7, 2011, https://doi.org/10.5352/JLS.2011.21.7.1016
  2. Antihyperglycemic and antioxidant activities of polysaccharide produced from Pleurotus ferulae in streptozotocin-induced diabetic rats vol.33, pp.6, 2016, https://doi.org/10.1007/s11814-016-0007-8