Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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The Inhibitory Principle of Lipopolysaccharide-Induced Nitric Oxide Production from Inula Britannica var. Chinensis

  • Je, Kang-Hoon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Han, Ah-Reum (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University) ;
  • Lee, Hyun-Tai (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University) ;
  • Mar, Woong-Chon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Seo, Eun-Kyoung (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University)
  • Published : 2004.01.01
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Abstract

A sesquiterpene lactone, 1-O-acetyl-4R,6S-britannilactone (1) isolated from the flowers of Inula britannica L. var. chinensis (Rupr.) Reg. (Compositae), was found as an iNOS inhibitory constituent for the first time with an $IC_{50}$ value of 22.1 $\mu$ M which is more potent than the positive control, L-$N^6$-(1-iminoethyl)lysine ($IC_{50} =33.7 \mu$ M). Structure of compound 1 was identified by 1D and 2D NMR experiments and by comparison with the reference standard.

Keywords

References

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