Archives of Pharmacal Research

  • 제27권10호
  • /
  • Pages.990-996
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  • 2004
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Synthesis and Antifungal Activity of 5,8-Quinazolinedione Derivatives Modified at Positions 6 and 7

  • Ryu, Chung-Kyu (College of Pharmacy, Ewha Womans University) ;
  • Shim, Ju-Yeon (College of Pharmacy, Ewha Womans University) ;
  • Yi, You-Jin (College of Pharmacy, Ewha Womans University) ;
  • Choi, Ik Hwa (College of Pharmacy, Ewha Womans University) ;
  • Chae, Mi-Jin (College of Pharmacy, Ewha Womans University) ;
  • Han, Ja-Young (College of Pharmacy, Ewha Womans University) ;
  • Jung , Ok-Jai (College of Pharmacy, Ewha Womans University)
  • 발행 : 2004.01.01
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초록

5,8-Quinazolinediones modified at positions 6 and 7 were synthesized and tested for in vitro antifungal activities against Candida species and Aspergillus niger. Most of 5,8-quinazolinediones 3-5 generally exhibited potent antifungal activity. 6-Arylamino-7-chloro-5,8-quinazolinediones (3) generally showed more potent antifungal activity than 7-arylthio-5,8-quinzolinediones (4) and 6,7-bis-(arylthio)-5,8-quinazolinediones (5).

키워드

참고문헌

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