Nutritional Sciences

The Korean Nutrition Society (한국영양학회)
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The Inhibitory Activity of Polygonum Multiflorum Thunberg and its Effect on Postprandial Hyperglycemia in Streptozotocin-induced Diabetic Rats

  • Kang Min-Jung (Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University) ;
  • Kim Jung-In (Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University) ;
  • Joo Hee-Jeong (Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University) ;
  • Seo Tae-Jin (Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University) ;
  • Kim Hyun-Ah (Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University) ;
  • Han Jung-Hee (Department of Nutrition, Pusan Paik Hospital)
  • Published : 2005.11.01
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Abstract

To keep blood glucose levels as close to normal as possible is the major goal of diabetes mellitus treatment $\alpha$-Glucosidase is the enzyme that digests die1my carbohydrate and inhibition of this enzyme may suppress postprandial hyperglycemia. The methanol extract of Polygonum multiflorum Thunberg was tested for inhibitoty activity against $\alpha$-glucosidase in vitro and in vivo. Polygonum multiflorum Thunberg extract inhibited yeast $\alpha$-glucosidase activity in a concentration-dependent manner. Polygonum multiflorum Thunberg showed an $IC_{50}$ value of 0.48 mg/mL. The ability of Polygonum multiflorum Thunberg extract to lower postprandial glucose was studied in streptozotocin-induced diabetic rats. A starch solution (1 g/kg) with and without the methanol extract of Polygonum multiflorum Thunberg extract (500 mg/kg) was administered to diabetic rats by gastric intubation after an overnight fast A single oral dose of Polygonum multiflorum Thunberg extract significantly inhibited increases in blood glucose levels at 60 and 90 min (p<0.05) and significantly decreased incremental response areas under the glycemic response curve (p<0.05). These results suggest that Polygonum multiflorum Thunberg may have an antihyperglycemic effect by inhibiting $\alpha$-glucosidase activity in the animal model of diabetes mellitus.

Keywords

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