Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Clinical and histopathological study using platelet-rich plasma and bone graft in the localized alveolar bone defects

치조제 결손부에 매식체 식립 시 혈소판 농축 혈장과 골이식술의 사용이 골형성에 미치는 영향에 대한 임상 및 조직 병리학적 연구

  • Jung, Ui-Young (Department of Periodontology, College of Dentistry, Dan-Kook University) ;
  • Lim, Sung-Bin (Department of Periodontology, College of Dentistry, Dan-Kook University) ;
  • Chung, Chin-Hyung (Department of Periodontology, College of Dentistry, Dan-Kook University) ;
  • Hong, Ki-Seok (Department of Periodontology, College of Dentistry, Dan-Kook University) ;
  • Lee, Chong-Heon (Department of Pathology, College of Dentistry, Dan-Kook University)
  • 정의영 (단국대학교 치과대학 치주과학교실) ;
  • 임성빈 (단국대학교 치과대학 치주과학교실) ;
  • 정진형 (단국대학교 치과대학 치주과학교실) ;
  • 홍기석 (단국대학교 치과대학 치주과학교실) ;
  • 이종헌 (단국대학교 치과대학 병리학교실)
  • Published : 2005.03.30
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Abstract

Alveolar ridge defects may limit or restrict placement of implants. The purpose of this study was to evaluate clinical and histopathologic results which occur following guided bone regeneration using platelet-rich plasma, bovine bone powder and e-PTFE membrane in the localized alveolar bone defects. Ten patients who required guided bone regeneration in implant placemnet, were slelected. Alveolar crest height and width were measured at baseline and, afer 2nd surgery 5 months later At 5 months , we obtained histopathological results as follows: 1. Alveolar crest height was an average of $8.20{\pm}3.74$ mm preoperatively and decreased to an average of $7.40{\pm}1.84$ mm postoperatively. There was no significant difference. 2. Alveolar crest width was an average of $4.25{\pm}2.03$ mm preoperatively and significantly increased to an average of $7.20{\pm}2.44$ mm postoperatively (P<0.01) 3. The change of Alveolar crest height and width were $0.80{\pm}1.40$ mm, $2.95{\pm}1.09$ mm 4. Histopathological evaluations revealed new bone formation with graft material and laminated bone containing the presence of osteocyte-like cell In conclusion, guided bone regeneration using platelet-rich plasma, bovine bone powder and e-PTFE membrane would provide a viable therapeutic alternative for implant placement in the localized alveolar defect or implant failure

Keywords

References

  1. Branemark PI, Zarb G, Albrektsson T : Tissueintegrated Prostheses. Osseo integration in Clinical Dentistry. Chicago, Quintessence, 1985
  2. Adell R, Lekholm U, Rockler B, et al, : A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int F Oral Surg 1981;10:387-416 https://doi.org/10.1016/S0300-9785(81)80077-4
  3. Jemp T, Lekholm U, Adell R : Osseointegrated implants in the traeatment of partially edentulous patients. A preliminary study of 876 consecutively installed fixtures. Int J Oral Maxillofac Implants 1989;4:211-217
  4. Jemt T, Lekholm U, Grandahl K : A 3-year follow-up study of early single implant restoration s ad modum Branemark. Int J Periodont Rest Dent 1990;10:341-349
  5. Sobolik CF: Alveolar bone resorption: J Prosthet Dent 1960;10: 612-619 https://doi.org/10.1016/0022-3913(60)90240-7
  6. Atwood DA: Some clinical factors related to rate of resorption of residual ridge: J Prosthet Dent 1962;12:441-450 https://doi.org/10.1016/0022-3913(62)90125-7
  7. Atwood DA: Postextraction changes in the adult mandible as illustrated by microradiographs of midsagittal sections and serial cephalometric roentgenograms: J Prosthet Dent 1963;13:810-824 https://doi.org/10.1016/0022-3913(63)90225-7
  8. Atwood DA: Reduction of residual ridges: A major oral disease entity: J Prosthet Dent 1971;26:266-279 https://doi.org/10.1016/0022-3913(71)90069-2
  9. Atwood DA, Coy WA: Clinical, cephalometric and densitometric study of reduction of residual ridges: J Prosthet Dent 1971; 26: 280-291 https://doi.org/10.1016/0022-3913(71)90070-9
  10. Dahlin C, Linde A, Gottlow F, Nyman S : Healing of bone defects by guided tissue regeneration. Plast Reconstr Surg 1988;81:672-676 https://doi.org/10.1097/00006534-198805000-00004
  11. Dahlin C, Sennerby L, Lekholm U, Linde A, Nyman S : Generation of new bone around titanium implants using a membrane technique: An experimental study in rabbits. Int J Oral Maxillofac Implats 1989;4:19-25
  12. Becker W, Becker BE, Handelsman M, Celletti R, Ochsenbein C, Hardwick R, Langer B : Bone formation at dehisced dental implant sites treated with implant augmentation material: A pilot study in dogs. Int J Periodot Res Dent 1990;10:93-102
  13. Gottlow J, Nyman S, Lindhe J, Karrind T : New attachment formation in the human periodontium by guided tissue regeneration. J Clin Periodontol 1986;13:604-616 https://doi.org/10.1111/j.1600-051X.1986.tb00854.x
  14. Dahlin C, Lekholm U, Becker W, Becker BE, Higuchi K, van Steenberghe D : Treatment of fenestration and dehiscence bone defect s around oral implants using the guided tissue regeneration technique : A multicenter prospective study. Int J Oral Maxillofac Implants 1995;10:312-318
  15. Brunsvold M, Mellonig j : Bone grafr and periodontal regeneration. Periodontol 2000 1993;1:80-91 https://doi.org/10.1111/j.1600-0757.1993.tb00209.x
  16. Hiatt R, Schallhom R : Intraoral transplants of cancellous bone and marrow in periodontal lesions. J Periodontol 1973;44:194-208 https://doi.org/10.1902/jop.1973.44.4.194
  17. Urist MR, Strates BS : Bond morphogenic protein. J Dent Res 1971;50:1392-1406 https://doi.org/10.1177/00220345710500060601
  18. Mellonig JR, Bowers GM, Catton WR : Comparison of bone grafe materials. II. New bone formation with autografts and allografts. A histological evaluation. J Periodontol 1981;52:297-302 https://doi.org/10.1902/jop.1981.52.6.297
  19. Bowers GM, Chadroff B, Carnevale R, et al : Histologic evaluation of mew attachment apparatus formation in humans. Part III. J Periodontal 1989;60:683-693 https://doi.org/10.1902/jop.1989.60.12.683
  20. Marx RE, Carlson ER, Eichstaedt RH, Schimmele SR, Strauss JE, Georgeff KR : Platelet-rich plasma : Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol 1998;85:638-646 https://doi.org/10.1016/S1079-2104(98)90029-4
  21. Wartiovaara U, Salven P, Mikkola H, et al : Peripheral blood platelers express VEGF-C and VEGF which are released during platelet activation. Thromb Haemost 1998;80:171-175
  22. Canalis E, Mc Carthy TL, Centrella M : The role of growth factors in skeletal remodeling. Endocrinol Meta Clin North Am 1989;18:903-912
  23. Antoniades HN, Scher CD, Stiles CD : Purification of human platelet -derived growth factors. Cell Biol 1979;76:1809-1813
  24. Pfeilschifer J, Oechsner M, Naumann A, Gronwald RGK, Minne HW, Ziegler R : Stimulation of bone matrix apposition in vitro by local growth factors : A comparison between insulin-like growth factor I, platelet-derived growth factors, and transforming growth factors. Endocrinology 1990;127:69-75 https://doi.org/10.1210/endo-127-1-69
  25. Lynch SE, Colvin RB, Antoniades HN : Growth factors in wound healing : Single and synergistic effects on partial thickness porcine skin wounds. J Clin Invest 1989;84:640-646 https://doi.org/10.1172/JCI114210
  26. Postlethwaite AE, Jorma KO, Moses HL, Kang AH : Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor. J Exp Med 1987;65:251-256
  27. Jensen J, Simonsen EK, Sindet-Pedersen S. Reconstruction of the severely resorbed maxilla with bone grafting and osseointegrated implants : J Oral Maxillofac Surg 1990;48:27-32 https://doi.org/10.1016/0278-2391(90)90175-2
  28. Keller EE, Van Roekel NB, Desjardins RP, Tolman DE, Prosthetic-surgical reconstruction of the severely resorbed maxilla with iliac bone grafting and tissue-integrated prosthesis. Int J Oral Maxillofac Implants 1987;2:155-165
  29. Misch CM, Misch CE, REsnik RR, Ismail YH. Reconstruction of maxillary alveolar defects with mandibular symphysis grafts for dental implants:A preliminary procedural report. Int J Oral Maxillofac Implants 1992;7:360-366
  30. Dahlin C, Lekholm U, Linde A. Membrane-induced bone augmentation at titanium implants. A report on the fixtures followed from 1 to 3 years after loading. Int J Periodontics Restorative Dent 1991;11:273-281
  31. Simion M. Trisi P, Piattelli A. Vertical ridge augmentation using a membrane technique associated with osseointegrated implants. Int J Periodontics Restorative Dent 1994;14:496-511
  32. Buser D, Bragger U, Lang NP, Nyman S. Regeneration and enlargement of jaw bone using guided tissue regeneration. Clin Oral implants Res 1990;1:22-32 https://doi.org/10.1034/j.1600-0501.1990.010104.x
  33. Simion M. Trisi P, Piattelli A. GBR with and e-PTFE membrane associated with DFDBA: Histologic and histochemical analysis in a human implant retrieved after 4 years of loading. Int J Periodontics Restorative Dent. 1996;16:338-347
  34. Buser D, Dula K, Belser UC, Hirt HP, Berthold H : Localized ridge augmentation using guided bone regeneration. I. Surgical procedure in the maxilla. Int J Periodont Rest Dent 1993;13:29-45
  35. Buser D, Dula K, Belser UC, Hirt HP, Berthold H : Localized ridge augmentation using guided bone regeneration. In.Guided Bone Regeneration in Implat Dentistry. Edited by Buser D, Dahlin C, Schenk RK. Chicago, Quintessence: 1994: 189-233
  36. Fugazzotto PA: Ridge augmentation with titanium screws and guided tissue regeneration: Technique and report of a case. Int J Oral Maxillofac Implants 1993;8:335-339
  37. Becker W, Becher BE, McGuire MK : Localized ridge augmentation using absorbable pins and e-PTFE barrier membranes: A new surgical technique. Case reports. Int J Periodont Rest Dent 1994;14:49-61
  38. Simion M, Dahlin C, Trisi P, Piattelli A: Qualitative and quantitative comparative study on different filling materials used in bone tissue regeneration: A controlled clinical study. Int J Periodont Rest Dent 1994;14:199-215
  39. Hammerle CH, Chiantella GC, Karring T, Lang NP: The effect of a deproteinized bovine bone mineral on bone regeneration around titanium dental implats. Clin Oral Implants Res 1998;9:151-162 https://doi.org/10.1034/j.1600-0501.1998.090302.x
  40. Nyman S, Gottlow J, Lindhe J, Karring T, Wennstrom J : New attachment formation by guided tissue regeneration. J Periodont Res 1987;22:252-254 https://doi.org/10.1111/j.1600-0765.1987.tb01581.x
  41. Becker W, Becker B, Berg L, Prichard J, Caffesse R, Resenberg E : New attachment after treatment with root isolation and vertical osseous defects. Int J Periondontics Restorative Dent 1988;8:8-23
  42. Pontoriero R, Lindhe J, Nyman S, Karring T, Rosenberg E, Sanavi F : Guided tissue regeneration in degree II furcation-involved mandibular molars. A clinical study. J Clin Periodontol 1988;15:247-254 https://doi.org/10.1111/j.1600-051X.1988.tb01578.x
  43. Simion M, Baldoni M, Rossi P, Zaffe D: Comparative study of effectiveness of GTAM membranes with and without early exposure during the healing period. Int J Periodont Rest Dent 1994;14:167-180
  44. Shanaman RH: A retrospective study of 237 sites teated consecutively with guided tissue regeneration. Int J Peirodont Rest Dent 1994;14:154-163
  45. Jovanovic SA, spiekermann H, Richter EJ Bone regeneration around titanium dental implants in dehisced defect sites: a clinical study. Int J Oral Maxillofac Implants 1992;7:233-245
  46. Buser D, Dula K, Hirt HP, Schenk RK: Lateral ridge augmentation using autografts and barrier membranes: a clinical with 40 partially edentulous patients. J Oral Maxillofac Surg. 1996;54:420-432 https://doi.org/10.1016/S0278-2391(96)90113-5
  47. Celletti R, Davarpanah M, Etienne D, Pecora G, Tecucianu JF, Djukanovic D, Donath K: Guided tissue regeneration around dental implants in immediate extraction sockets: comparison of a e-PTFE and a new titanium membrane. Int J Periodontics Restorative Dent. 1994;14:242-253
  48. Schliephake H, Dard M, Planck H, Hierlemann H, Stern U: Alveolar ridge repair using resorbable membranes and autogenous bone particles with simultaneous placement of implants: an experimental pilot study in dogs. Int J Oral Maxillofac Implants. 2000;15:364-373
  49. Whitman DH, Berry RL: A technique for improving the handling of particulate cancellous bone and marrow grafts using platelet gel. J Oral Maxillofac Surg 1998;56:1217-1218 https://doi.org/10.1016/S0278-2391(98)90776-5