Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Transdermal Delivery of Piroxicam Using Microemulsions

  • Park Eun-Seak (College of Pharmacy, Sungkyunkwan University) ;
  • Cui Yu (College of Pharmacy, Sungkyunkwan University) ;
  • Yun Bum-Jin (College of Pharmacy, Sungkyunkwan University) ;
  • Ko In-Ja (College of Pharmacy, Sungkyunkwan University) ;
  • Chi Sang-Cheol (College of Pharmacy, Sungkyunkwan University)
  • Published : 2005.02.01
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Abstract

To improve the skin permeability of piroxicam, a new oil-in-water microemulsion containing $0.5\%$ piroxicam was developed. Among various oils investigated for their suitability as an oil phase for the microemulsion system, oleic acid showed both excellent solubility and skin permeation enhancing effect for piroxicam. Microemulsion existence ranges were identified through the construction of the pseudo-ternary phase diagram. The effect of the content of oleic acid and the ratio of the surfactant/cosurfactant on skin permeation of piroxicam were evaluated with excised rat skins. The optimum formulation with the highest skin permeation rate ($47.14\;{\mu}g/cm^2/h$) consisted of $0.5\%$ piroxicam, $10\%$ oleic acid, $60\%$ Labrasol/ethanol (1:5) and water.

Keywords

References

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