Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidant Activities of Vietnamese Medicinal Plants

  • Published : 2006.03.01
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Abstract

One hundred and twenty six Vietnamese traditional herbals belonging to 59 families were screened for their free radical (DPPH) scavenging activity and inhibitory effect on lipid peroxidation. Of these, MeOH extracts of seven plants, including Euphorbia thymifolia (leaf), Gnetum montanum (stem), Heterosmilax erythrantha (root), Morus alba (leaf), Syzygium formosum (leaf), Jussiaea repens (aerial parts), and Camellia sinensis (leaf), exhibited significant antioxidant activities. All of these herbs showed remarkable free radical scavenging activities with $IC_{50}$ values of 11.0, 14.5, 17.0, 13.6, 10.8, 7.7, and $8.5\;{\mu}g/ml$, respectively, and significant inhibitory effects on lipid peroxidation with 79.7, 83.8, 78.9, 82.5, 88.8, 88.0, and 96.2% inhibitions, respectively, at the concentration of $50\;{\mu}g/ml$.

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References

  1. Banerjee, A., Dasgupta, N., and De, B., In vitro study of antioxidant activity of Syzygium cumini fruit. Food Chem. 90, 727-733 (2005) https://doi.org/10.1016/j.foodchem.2004.04.033
  2. Brenner, A.J. and Harris, E.D., A quantitative test for copper using bicinchoninic acid. Anal. Biochem. 226, 80-84 (1995) https://doi.org/10.1006/abio.1995.1194
  3. Chen, Y., Wang, M.F., Rosen, R.T., and Ho, C.T., 2,2-Diphenyl-lpicrylhydrazyl radical-scavenging active components from Polygonum multiflorum Thunb. J. Agr. Food Chem. 47, 2226-2228 (1999) https://doi.org/10.1021/jf990092f
  4. Chi, V.V., Dictionary of Vietnamese medicinal plants. Medical Publishing House, Hanoi, Vietnam (1997)
  5. Doi, K., Kojima, T., Makino, M., Kimura, Y., and Fujimoto, Y., Studies on the constituents of the leaves of Morns alba L. Chem. Pharm. Bull. 49, 151-153 (2001) https://doi.org/10.1248/cpb.49.151
  6. Halliwell, B., Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 344, 721-724 (1994) https://doi.org/10.1016/S0140-6736(94)92211-X
  7. Halliwell, B., Aeschbach, R., Loliger, J., and Aruoma, O.I., The characterization of antioxidants. Food Chem. Toxicol. 33, 601-617 (1995) https://doi.org/10.1016/0278-6915(95)00024-V
  8. Ham, A.J.L. and Liebler, D.C., Vitamin E oxidation in rat liver mitochondria. Biochemistry 34, 5754-5761 (1995) https://doi.org/10.1021/bi00017a007
  9. Ho, P.H., 1997. Vietnamese Flora. Science and Technology Publishing House, Hanoi, Vietnam
  10. Huang, H.C., Shen, C.C., Chen, C.F., Wu, Y.C., and Kuo, Y.H., A novel agarofuran sesquiterpene, celahin D from Celastrus hindsii Benth. Chem. Pharm. Bull. 48, 1079-1080 (2000) https://doi.org/10.1248/cpb.48.1079
  11. Kim, S. Y., Gao, J.J., Lee, W.C., Ryu, K.S., Lee, K.R., and Kim, Y.C., Antioxidative flavonoids from the leaves of Morns alba. Arch. Pharm. Res. 22, 81-85 (1999) https://doi.org/10.1007/BF02976442
  12. Kimura, Y., Ohminami, H., Okuda, H., Baba, K., Kozawa, M., and Arichi, S., Effects of stilbene components of roots of Polygonum ssp. on liver injury in peroxidized oil-fed rats. Planta Med. 49, 51-54 (1983) https://doi.org/10.1055/s-2007-969810
  13. Kohen, R., and Nyska, A., Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol. Pathol. 30, 620-650 (2002) https://doi.org/10.1080/01926230290166724
  14. Kuo, Y.H., Chen, C.F., Kuo, L.M.Y., King, M.L., Chen, C.F., and Lee, K.H., Celahinine A, a new sesquiterpene pyridine alkaloid from Celastrus hindsii. J. Nat. Prod. 58, 1735-1738 (1995) https://doi.org/10.1021/np50125a015
  15. Kuo, Y.H., and Kuo, L.M.Y., Antitumor and anti-aids triterpenes from Celastrus hindsii. Phytochemistry 44, 1275-1281 (1997) https://doi.org/10.1016/S0031-9422(96)00719-4
  16. Lee, K.G, and Shibamoto, T., Antioxidant property of aroma extract isolated from clove buds (Syzygium aromaticum). Food Chem. 74, 443-448 (2001) https://doi.org/10.1016/S0308-8146(01)00161-3
  17. Lee, S.H., Tanaka, T., Nonaka, G., and Nishioka, I., Hydrolyzable tannins from Euphorbia thymifolia. Phytochemistry 29, 3621-3625 (1990) https://doi.org/10.1016/0031-9422(90)85288-Q
  18. Li, X.M., Lin, M., Wang, Y.H., and Liu, X., Four new stilbenoids from the lianas of Gnetum montanum f. megalocarpum. Planta Med. 70, 160-165 (2004) https://doi.org/10.1055/s-2004-815494
  19. Lin, C.C., Cheng, H.Y, Yang, C.M., and Lin, T.C., Antioxidant and antiviral activities of Euphorbia thymifolia L. J. Biomed. Sci. 9, 656-664 (2002)
  20. Loi, D.T., Vietnamese medicinal plants and ingredients. Medical Publishing House, Hanoi, Vietnam (2001)
  21. Na, M.K., An, R.B., Jin, W.Y., Min, B.S., Yoo, J.K., Kim, Y.H., and Bae, K.H., Antioxidant effects of plant extracts on free radicals and lipid peroxidation. Nat. Prod. Sci. 9, 226-231 (2003)
  22. Nam, N.H., Cytotoxic principle of Siegesbeckia orientalis growing in Vietnam. Tap Chi Hoa Hoc 38, 84-86 (2000)
  23. Nam, N.H., Kim, H.M., Bae, K.H., and Ahn, B.Z., Inhibitory effects of Vietnamese medicinal plants on tube-like formation of human umbilical venous cells. Phytother. Res. 17, 107-111 (2003) https://doi.org/10.1002/ptr.934
  24. Nam, N.H., Kim, Y., You, Y.J., Hong, D.H., Kim, H.M., and Ahn, B.Z., New constituents from Crinum latifolium with inhibitory effects against tube-like formation of human umbilical venous endothelial cells. Nat. Prod. Res. 18, 485-491 (2004) https://doi.org/10.1080/1057563031000122103
  25. Nam, N.H., Lee, C.W., Hong, D.H., Kim, H.M., Bae, K.H., and Ahn, B.Z., Antiinvasive, antiangiogenic and antitumour activity of Ephedra sinica extract. Phytother. Res. 17, 70-76 (2003) https://doi.org/10.1002/ptr.901
  26. Nguyen, M.T.T., Awale, S., Tezuka, Y., Tran, Q.L., Watanabe, H., and Kadota, S., Xanthine oxidase inhibitory activity of Vietnamese medicinal plants. Biol. Pharm. Bull. 27, 1414-1421 (2004) https://doi.org/10.1248/bpb.27.1414
  27. Nguyen, T.N.T, Kamenarska, Z., Bankova, V.. Popov, S., Zvetkova, E., Katzarovo, E., and Le, M.H., Cytotoxic activities of alkaloid fractions from Crinum latifolium L., Amaryllidaceae. Tap Chi Duoc Hoc 11, 21-23 (2001)
  28. Nonaka, G., Miwa, N., and Nishioka, I., Tannins and related compounds. Part 2. Stilbene glycoside gallates and proanthocyanidins from Polygonum multiflorum. Phytochemistry 21, 429-432 (1982) https://doi.org/10.1016/S0031-9422(00)95282-8
  29. Phan, T.S., Tran, B.D., Phan, M.G., Nguyen, T.M., Hoang, T.H., and Le, M.H., Investigation of antimicrobial and cytotoxic properties of alkaloids from some species of Crinum in Vietnam. Tap Chi Duoc Hoc 4, 18-21 (2003)
  30. Pietta, P.G., 2000. Flavonoids as antioxidants. J. Nat. Prod. 63, 1035-1042 https://doi.org/10.1021/np9904509
  31. Ryu, G.S., Ju, J.H., Park, Y.J., Ryu, S.Y., Choi, B.W., and Lee, B.H., The radical scavenging effects of stilbene glucosides from Polygonum multiflorum. Arch. Pharm. Res. 25, 636-639 (2002) https://doi.org/10.1007/BF02976935
  32. Simonian, N.A., and Coyle, J.T., Oxidative stress in neurodegenerative diseases. Ann. rev. Pharmacol. Toxicol. 36, 83-106 (1996) https://doi.org/10.1146/annurev.pa.36.040196.000503
  33. Xiang, W., Jiang, B., Li, X.M., Zhang, H.J., Zhao, Q.S., Li, S.H., and Sun, H.D., Constituents of Gnetum montanum. Fitoterapia 73, 40-42 (2002) https://doi.org/10.1016/S0367-326X(01)00370-7
  34. Yao, C.S., Zhou, L.X., and Lin, M., Preparation on oligostilbenes of isorhapontigenin by oxidative coupling reaction. Chem. Pharm. Bull. 52, 238-243 (2004) https://doi.org/10.1248/cpb.52.238
  35. Yen, G.C., and Hsieh, C.L, Antioxidant activity of extracts from Du-zhong (Eucommia ulmoides) toward various lipid peroxidation models in vitro. J. Agr. Food Chem. 46, 3952-3957 (1998) https://doi.org/10.1021/jf9800458
  36. Yen, G.C., Wu, S.C., and Dub, P.D., Extraction and identification of antioxidant components from the leaves of Mulberry (Morus alba L.). J. Agr. Food Chem. 44, 1687-1690 (1996) https://doi.org/10.1021/jf9503725
  37. You, Y.J., Nam, N.H., Kim, Y., Bae, K.H., and Ahn, B.Z., Antiangiogenic activity of lupeol from Bombax ceiba. Phytother. Res. 17, 341-344 (2003) https://doi.org/10.1002/ptr.1140
  38. Ueda, J.Y., Tezuka, Y., Banskota, A.H., Tran, Q.L., Tran, Q.K, Harimaya, Y., Saiki, I., and Kadota, S., Antiproliferative activity of Vietnamese medicinal plants. Biol. Pharm. Bull. 25, 753-760 (2002) https://doi.org/10.1248/bpb.25.753
  39. Waddington, R.J., Moseley, R., and Embery, G., Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases. Oral Dis. 6, 138-151 (2000) https://doi.org/10.1111/j.1601-0825.2000.tb00325.x
  40. Wu, L., Smythe, A.M., Stinson, S.P., Mullendore, L.A., Monks, A., Scudiero, D.A., Paull, K.D., Koutsoukos, A.D., Rubinstein, L.V., Boyd, M.R., and Shoemaker, R.H., Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening. Cancer Res. 52, 3029-3034 (1992)